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Thromb Haemost 1988; 59(03): 396-399
DOI: 10.1055/s-0038-1647503
Original Article
Schattauer GmbH Stuttgart

HIV-Antibody Seroconversions in Dutch Haemophiliacs Using Heat-Treated and Non Heat-Treated Coagulation Factor Concentrates

Tom F W Wolfs
The Human Retrovirus Laboratory of the Department of Virology and the Pediatric Department, The Netherlands
,
Cees Breederveld
*   The Division of Hemostasis and Thrombosis, Academic Medical Centre of the University of Amsterdam, The Netherlands
,
Willy J A Krone
The Human Retrovirus Laboratory of the Department of Virology and the Pediatric Department, The Netherlands
,
Lia v d Hoek
The Human Retrovirus Laboratory of the Department of Virology and the Pediatric Department, The Netherlands
,
Margreet Bakker
The Human Retrovirus Laboratory of the Department of Virology and the Pediatric Department, The Netherlands
,
Lia Smit
The Human Retrovirus Laboratory of the Department of Virology and the Pediatric Department, The Netherlands
,
Jaap Goudsmit
The Human Retrovirus Laboratory of the Department of Virology and the Pediatric Department, The Netherlands
,
The Dutch haemophilia group › Author Affiliations
Further Information

Publication History

Received 28 July 1986

Accepted after revision 19 January 1988

Publication Date:
26 July 2018 (online)

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Summary

A national multicentre study was performed to investigate the effects of donorselection and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983.

Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product.

Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.

Keywords

Acquired immune deficiency syndrome - Haemophilia - Factor VIII heat treatment - Seroconversion rate
 

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