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Thromb Haemost 1988; 59(03): 507-513
DOI: 10.1055/s-0038-1647525
Original Article
Schattauer GmbH Stuttgart

Effect of a Moderate Fish lntake on Platelet Aggregation in Human Platelet-Rich Plasma

A C v Houwelingen
1   The Department of Human Biology, Limburg University, Maastricht, The Netherlands
,
A A H M Hennissen
1   The Department of Human Biology, Limburg University, Maastricht, The Netherlands
,
F Verbeek-Schippersa
4   The TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands
,
T Simonsen
5   The Department of Medicine, University Hospital, University of Tromsø, Norway
,
A D M Kester
2   The Department of Medical Informatics and Statistics, Limburg University, Maastricht, The Netherlands
,
G Hornstra
3   The Department of Biochemistry, Limburg University, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 16 June 1987

Accepted after revision 24 February 1988

Publication Date:
29 June 2018 (online)

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Summary

This paper describes the results of an international study to investigate the effect of a reasonable amount of dietary fish on platelet aggregation in platelet-rich plasma (PRP) induced by collagen and thrombin. In Maastricht, Tiomsø, and Zeist two groups of healthy male volunteers were given a daily dietary supplement consisting of 135 g of canned mackerel paste (experimental group, n = 40) or meat paste (control group, n = 42) for a 6-week period. Compliance, calculated on the basis of the urinary excretion of lithium, added to the supplements, was about 80%. Platelet number in PRP decreased significantly in the fish group. Collagen-induced platelet aggregation in PRP differed widely between the three centres despite the attempt to use exactly the same conditions. Nonetheless, aggregation decreased significantly in the fish group. The mackerel effect on thrombin-induced aggregation was inconsistent.

Keywords

Fish - Diet - Compliance - Platelte aggregation - Platelte number - PRP - Collagen - Thrombin
 

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