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Thromb Haemost 1988; 60(01): 121
DOI: 10.1055/s-0038-1647647
Letter to the Editor
Schattauer GmbH Stuttgart

Sulphasalazine Increases Fibrinolysis in the Anaesthetised Rat

Phillip K Moore
Department of Pharmacology, King’s College, University of London, Manresa Road, London SW3 6LX, UK
,
Isa Hussaini
Department of Pharmacology, King’s College, University of London, Manresa Road, London SW3 6LX, UK
,
Renu Bhardwaj
Department of Pharmacology, King’s College, University of London, Manresa Road, London SW3 6LX, UK
› Author Affiliations
Further Information

Publication History

Received 27 January 1988

Accepted after revision 10 March 1988

Publication Date:
30 June 2018 (online)

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  • References

  • 1 Goldman PA, Peppercorn MA. Sulfasalazine. N Engl J Med 1975; 293: 20-23
    CrossrefPubMedGoogle Scholar
  • 2 Bach MK, Brashler JR, Johnson MA. Inhibition by sulphasalazine of LTC synthetase and of rat liver glutathione S-transferases. Biochem Pharmacol 1985; 34: 2695-2704
    CrossrefPubMedGoogle Scholar
  • 3 Molin L, Stendahl O. The effect of sulphasalazine and its active components on human polymorphonuclear leucocyte function in relation to ulcerative colitis. Acta Med Scand 1979; 206: 451-454
    PubMedGoogle Scholar
  • 4 Broughton-Smith NK, Hawkey CJ, Rosam AC, Whittle BJ R. Sulphasalazine inhibits platelet aggregation and thromboxane formation in human platelets and kidney. Br J Pharmacol 1986; 88: 391 P
    PubMedGoogle Scholar
  • 5 Farr M, Tunn E, Bacon PE, Smith DH. Hypogammaglobulinaemia and thrombocytopaenia associated with sulphasalazine therapy in rheumatoid arthritis. Ann Rheum Dis 1985; 44: 723-724
    PubMedGoogle Scholar
  • 6 Mechanick JI. Coomb’s positive hemolytic anaemia following sulphasalazine therapy in ulcerative colitis: case reports, reviews, and discussion of pathogenesis. Mt Sinai J Med NY 1985; 52: 667-670
    PubMedGoogle Scholar
  • 7 Nilsson IM, Olow B. Fibrinolysis induced by streptokinase in man. Acta Chir Scand 1962; 123: 247-266
    PubMedGoogle Scholar
  • 8 Hussaini I, Moore PK. Fibrinolytic effect of prostanoids in the rat. Br J Pharmacol 1985; 86: 813 P
    PubMedGoogle Scholar
  • 9 Tranquille N, Erneis JJ. Release of tissue type plasminogen activator is induced in rats by leukotrience C4 and D4, but not prostaglandins E1, E2 and I2 . Br J Pharmacol 1988; 93: 156-164
    CrossrefPubMedGoogle Scholar
  • 10 Hoult JRS, Moore PK, Ramcharan E. Sulphasalazine inhibits the pulmonary inactivation of prostaglandins in the rat in vivo. Br J Pharmacol 1979; 66: 101 P
    PubMedGoogle Scholar