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Thromb Haemost 1974; 32(02/03): 538-548
DOI: 10.1055/s-0038-1647722
Original Article
Schattauer GmbH

Severe Factor V Deficiency with Prolonged Bleeding Time

Kees Bkeederveld
1   Coagulation Laboratory, Department of Haematology, University Hospital “ Wilhelmina Gasthuis”, Amsterdam, The Netherlands
,
Eric A. van Royen
1   Coagulation Laboratory, Department of Haematology, University Hospital “ Wilhelmina Gasthuis”, Amsterdam, The Netherlands
,
Jan W. ten Cate
1   Coagulation Laboratory, Department of Haematology, University Hospital “ Wilhelmina Gasthuis”, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 12 June 1974

Accepted 11 July 1974

Publication Date:
30 June 2018 (online)

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Summary

A patient with two congenital defects, i.e. a severe factor V deficiency and an aortic coarctation is described. Arguments for a dominant mode of inheritance of the factor V deficiency are presented. A coinciding haemostatic defect consisting of a prolonged bleeding time, which could be corrected by fresh plasma and cryoprecipitate, and a decreased platelet retention in the glass bead test disappeared after surgical correction of the coarctation.

Extensive platelet studies failed to show any further defect.

 

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