The Plasminogen-Plasmin System Part VIII On the Mechanism of Chemical Induction of Fibrinolysis Isolation of a Latent Plasminogen Activator from Human Plasma

Munehiro Tomikawa; Yasushi Abiko

doi:10.1055/s-0038-1647745

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1973; 29(01): 050-062
DOI: 10.1055/s-0038-1647745

Original Article

Schattauer GmbH

The Plasminogen-Plasmin System Part VIII On the Mechanism of Chemical Induction of Fibrinolysis Isolation of a Latent Plasminogen Activator from Human Plasma

Munehiro Tomikawa

¹Research Laboratories, Daiichi Seiyaku Co., Ltd., Edogawa-ku, Tokyo, Japan

,

Yasushi Abiko

¹Research Laboratories, Daiichi Seiyaku Co., Ltd., Edogawa-ku, Tokyo, Japan

› Institutsangaben

Abstract

Summary

A component, responsible for the chemical induction of fibrinolysis by flufenamate, was isolated from human plasma. The isolation procedures included removal of euglobulin precipitate from plasma, Sephadex G-200 gel filtration of the euglobulin- supernatant fraction and isoelectric focusing. The partially purified component was immunologically distinct from ßioglobulin, plasmin and plasminogen. Plasminogen activator activity was liberated from the component by treatment with flufenamate. The mechanism of induction of fibrinolysis by flufenamate is discussed.

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References
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