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Thromb Haemost 1973; 29(01): 190-195
DOI: 10.1055/s-0038-1647759
Original Article
Schattauer GmbH

Effects “in Vitro” of Some Cardiovascular Drugs and Other Agents on Human Platelet Aggregation

G Sacchetti
1   Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)
,
D Bellani
1   Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)
,
C Montanari
1   Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)
,
A Gibelli
1   Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)
› Author Affiliations
Further Information

Publication History

Received 24 July 1972

Publication Date:
24 July 2018 (online)

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Summary

The in vitro effect of the following substances on human platelet aggregation is studied: K 4423 (a ß-blocking drug), isoproterenol, phentolamine, papaverine, methamidoline (a myolytic agent).

None of these substances causes aggregation. All inhibit aggregation induced by ADP or noradrenaline, except for phentolamine, which is active only on noradrenaline- induced aggregation.

Hypothesis on the mechanism of action of the compounds tested are proposed.

 

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