Thromb Haemost 1973; 29(02): 240-246
DOI: 10.1055/s-0038-1647767
Original Article
Schattauer GmbH

Immunoreactive Factor VIII in Carriers of Hemophilia A+ and A-

K Lechner
1   Central Coagulation Laboratory, First Department of Medicine, University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 21 October 1972

Publication Date:
30 June 2018 (online)

Summary

Factor VIII activity and inhibitor-neutralizing capacity of plasmas of 30 probable or definite carriers of hemophilia A were compared. The inhibitor-neutralization test is less useful to recognize the carrier-state than the factor VIII assay. Plasmas of two carriers belonging to families (in which, in at least one member, the diagnosis of hemophilia A+ was established) had an inhibitor neutralizing capacity twice as high as expected from the biological activity, while 28 carriers from hemophilia A- families had an inhibitor neutralizing-capacity equivalent to their factor VIII activity.

 
  • References

  • 1 Bentley H. P, Kmvit W. 1960; An assay of antihemophilic globulin activity in the carrier female. Journal Laboratory Clinical Medicine 56: 613.
  • 2 Biggs R, Bidwell E. 1959; A method for the study of antihaemophilic globulin inhibitors with reference to six cases. British Journal Haematology 05: 379.
  • 3 Denson K. W. E, Biggs R, Haddon M. D, Borrett R, Cobb K. 1969; Two types of haemophilia (A+ and A”) : a study of 48 cases. British Journal Haematology 17: 163.
  • 4 Deutsch E, Kook M. 1962; Beitrag zur Objektivierung der Diagnose der hämophilen Kondukt or in. Wiener Klinische Wochenschrift 74: 793.
  • 5 Githens J. H, Wilcox P. J. 1962; The carrier state in hemophilia. American Journal Medicine 60: 77.
  • 6 Hoyee L. W, Breckeneidge R. T. 1968; Immunologie studies of antihemophilic factor (AHF, factor VIII) : crossreacting material in a genetic variant of hemophilia A. Blood 32: 962.
  • 7 Larrietu M. J, Meyer D. 1971; Heterogeneity of factor VIII and factor IX variants. Thrombosis et Diathesis Haemorrhagica (suppl.) 63: 11.
  • 8 Lechner K. 1972; Inactive factor VIII in hemophilia A and in Willebrand’s disease. A study of 117 cases. Acta Haematologica 48: 257.
  • 9 Margoletjs A, Ratnoff O. D. 1956; A laboratory study of the carrier state in classical hemophilia. Journal Clinical Investigation 39: 1619.
  • 10 Miller S. P, Siggertjd J. 1964; Abnormal blood coagulation in carriers of hemophilia. Journal Laboratory Clinical Medicine 63: 621.
  • 11 Nilsson I. M, Blombäck M, Ramgren O, v. Feancken I. 1962; Haemophilia in Sweden. II. Carriers of hemophilia A and B. Acta Medica Scandinavica 171: 223.
  • 12 Pfanzagl J. 1966 Allgemeine Methodenlehre der Statistik. vol. 2. (Gruyter, Berlin)
  • 13 Rapaport S. I, Patch M. J, Moore F. J. 1960; Antihemophilic globulin levels in carriers of hemophilia A. Journal Clinical Investigation 39: 1619.
  • 14 Roberts H. R, Grizzle J. E, McLester W. D, Penick G. D. 1968; Genetic variants of hemophilia B; detection by means of specific PTC inhibitor. Journal Clinical Investigation 47: 360.
  • 15 Veltkamp J. J, Drion E. F, Loeliger E. A. 1968; Detection of the carrier state in hereditary coagulation disorders. II. Thrombosis et Diathesis Haemorrhagica 19: 403.
  • 16 Zimmermann T. S, Ratnoff O. D, Littell A. S. 1971; Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor VIII). Journal Clinical Investigation 50: 255.