Thromb Haemost 1973; 29(02): 293-299
DOI: 10.1055/s-0038-1647772
Original Article
Schattauer GmbH

Insulin and Blood Fibrinolytic Activity

Anne M Hedlin Ph.D.
1   Department of Physiology, Faculty of Medicine, Medical Sciences Building, University of Toronto
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 17. August 1972

Publikationsdatum:
24. Juli 2018 (online)

Summary

The effect of insulin on fibrinolysis was studied in hospital patients who were subjected to an insulin tolerance or glucose tolerance test. Blood samples were obtained at frequent intervals over a 2-3 hour period and fibrinolytic activity determined by the dilute whole blood lysis test. Normal control subjects were tested in both fasting and in non-fasting states. A marked increase in fibrinolytic activity was produced during the insulin tolerance test. However, as this increase did not appear until the blood glucose had been reduced to 30-40 mg % it was considered to be due, not to the insulin which had been administered, but rather to the action of those hormones which would be released in response to the hypoglycemia. On the other hand, the results of the glucose tolerance test demonstrated a gradual increase in fibrinolysis during the test period. Again this increased activity could not be attributed to the action of insulin because a similar effect was apparent in the samples obtained from the control subjects. Therefore, it was concluded that the enhancement of fibrinolysis observed in both test and control subjects was not due to the action of insulin.

 
  • References

  • 1 Belawiec M, Perzanowski A, Myslintec M. 1970; Studies on the fibrinolytic activity of blood in diabetics (in Polish). Polski Tygodnik Lekarski 25: 85.
  • 2 Biggs R, Macfaelane R. G, Pilling G. 1947; Observations on fibrinolysis. Experimental activity produced by exercise or adrenalin. Lancet I: 402.
  • 3 Grolle G, Gaebeeo F, Certjtti G, Delpiano G. C. 1968; Effect of insulin on the early phases of blood clotting, free fatty acids and fibrinolysis. Archivio per le scienze mediche 125: 67.
  • 4 Endo K. 1970; Blood fibrinolytic activity in diabetics - before and after treatment (in Japanese). The Journal of the Japanese Society of Internal Medicine 59: 16.
  • 5 Feaenley G. R, Balmforth G, Feaenley E. 1957; Evidence of a diurnal fibrinolytic rhythm with a simple method of measuring natural fibrinolysis. Clinical Science 16: 645.
  • 6 Fearnley G. R, Vincent C. T, Chakrabarti R. 1959; Reduction of blood fibrinolytic activity in diabetes mellitus by insulin. Lancet II: 1067.
  • 7 Goldfien A, Moore R, Zileli S, Havens L, Boling L, Thorn G. W. 1961; Plasma epinephrine and norepinephrine levels during insulin-induced hypoglycemia in man. J ournal of Clinical Endocrinology and Metabolism 21: 296.
  • 8 Hedlin A. M, Monkhouse F. C. 1971; Changes in spontaneous fibrinolytic activity during use of oral contraceptives. Obstetrics and Gynecology 37: 225.
  • 9 Rosing D. R, Brakman P, Redwood D. R, Goldstein R. E, Beisner G. D, Astrup T, Epstein S. E. 1970; Blood fibrinolytic activity in man. Circulation Research 27: 171.
  • 10 Sharma S. D, Malhotra P. P. 1969; Blood fibrinolytic activity in diabetics. Indian Journal of Medical Sciences 23: 366.