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Thromb Haemost 1973; 29(02): 363-374
DOI: 10.1055/s-0038-1647778
Original Article
Schattauer GmbH

Fibrin Derivatives, Plasma Hemoglobin and Glomerular Fibrin Deposition in Experimental Intravascular Coagulation

F. K Beller   *
1   Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, cmd Westfaelische Wilhelms Universitaet, Muenster, Germany
,
W Theiss   +
1   Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, cmd Westfaelische Wilhelms Universitaet, Muenster, Germany
› Author Affiliations
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Publication History

Received 04 August 1972

Publication Date:
30 June 2018 (online)

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Summary

Plasma fibrinogen, circulating fibrinmonomers (as indicated by a positive ethanol gelation test), fibrinolysis breakdown products and plasma hemoglobin were assayed in 122 rats subjected to endotoxin injection or infusion. The results were correlated with the quantitative measurement of glomerular fibrin deposition. Based on these data four groups were determined : consumption coagulopathy and three stages of increasing severity of disseminated intravascular coagulation (DIG).

Consumption coagulopathy was defined by a decrease in plasma fibrinogen and a positive ethanol gelation test in the absence of glomerular fibrin deposition. Plasma hemoglobin and fibrinolysis breakdown products were normal or only slightly increased.

DIG as characterized by glomerular fibrin deposition was defined as moderate (1 to 20% glomeruli showing fibrin strands), intermediate (21 to 80%), and severe (81 to 100%). Decrease in plasma fibrinogen and frequence of a positive ethanol gelation test in all stages of DIG were only slightly different from the findings in consumption coagulopathy. However, a sharp increase in plasma hemoglobin levels was noted when glomerular fibrin deposition did occur even in small amounts. At this time only a moderate increase was noted in fibrin(ogen) breakdown products. These two parameters increased only slightly in the group of intermediate DIG. Severe DIG was characterized by a massive increase in fibrin (ogen) breakdown products and high levels of plasma hemoglobin.

* Present address: Univ. Fnmenklinik, Münster, Westfalen, Germany.


+ Research Fellow in human reproduction. Present address: I. Medizinische Klinik rechts der Isar der Technischen Universität, Munich, Germany.


 

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