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Thromb Haemost 1975; 33(03): 606-609
DOI: 10.1055/s-0038-1647855
International Committee on Thrombosis and Haemostasis Task Force
Schattauer GmbH

Serologic Evidence for Hepatitis B Virus Infection in Patients with Hemophilia B[*]

A Multicenter Study
Jay H Hoofnagle
1   Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland, 20014, U.S.A.
2   University of North Carolina Medical School, Chapel Hill, North Carolina, U.S.A.
,
David Aronson
1   Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland, 20014, U.S.A.
2   University of North Carolina Medical School, Chapel Hill, North Carolina, U.S.A.
,
Harold Roberts
1   Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland, 20014, U.S.A.
2   University of North Carolina Medical School, Chapel Hill, North Carolina, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 30 January 1975

accepted 30 January 1975

Publication Date:
02 July 2018 (online)

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Summary

Among sera from 160 patients with hemophilia B from 9 centers in Europe and North and South America, 2.5% were positive for hepatitis B surface antigen (HBsAg), 60% for antibody to HBsAg, and 31% for antibody to the hepatitis B core antigen. Evidence of exposure to the hepatitis B virus appeared to be related to severity of disease and age rather than the source and method of manufacturer of factor IX concentrate.

* Task Force Report


 

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