What Can be Done and What is Worth Doing: Thoughts on Limits and Priorities

Gustav V. R Born

doi:10.1055/s-0038-1647906

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 35(01): 006-023
DOI: 10.1055/s-0038-1647906

Original Article

Schattauer GmbH

What Can be Done and What is Worth Doing: Thoughts on Limits and Priorities

Third Shirley A. Johnson Memorial Lecture^[*]

Gustav V. R Born

¹Department of Pharmacology, University of Cambridge, Cambridge CB2 2QD, England

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Abstract

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References

Reference
1 Ashby Lord. 1975 Report of the working party on the experimental manipulation of the genetic composition of micro-organisms. H. M. Stationery Office (Cmd. 5880) London.
2 Born G. V. R, Bergquist D, Afors K.-E. 1976 Evidence for the prevention of platelet activation in blood by a drug effect on the red cells. Nature (in the press).
3 Born G. V. R, Cross M. J. 1963; a Inhibition of the aggregation of blood platelets by substances related to adenosine diphosphates. Journal of Physiology 166: 29P.
4 Born G. V. R, Cross M. J. 1963; b The aggregation of blood platelets. Journal of Physiology 168: 178.
5 Born H, Born M. 1969. Einstein ganz privat. In: Der Luxus des Gewissens. Nymphenburger Verlag: München; 117.
6 Born M. 1969. Statistical interpretation of quantum mechanics. In: Physics in my Generation.. Springer; New York:
7 Born M. 1969. Symbol and reality. In: Physics in my Generation.. Springer; New York: 142.
8 Born M, Brandt W, Born G. V. R. 1950; In memoriam Gustav Born, experimental embryologist. Acta Anatomica (Basel) 10: 466.
9 Burton A. C. 1975; Variety – the spice of science as well as of life. In: Annalytical Review of Physiology 37: 1.
10 Busch W. 1882. Plisch and Plum. In: Wilhelm Busch Album. Rascher Verlag: Zürich (1945); 310.
11 Cuthbertson W. F. J, Mills D. C. B. 1963; Some factors influencing platelet clumping. Journal of Physiology 169: 9P.
12 Downie H. G, Murphy E. A, Rowsell H. C, Mustard J. F. 1963; Extracorporeal circulation: a device for the quantitative study of thrombus formation in flowing blood. Circulation Research 12: 441.
13 Edwards C, Edwards L. 1972. Concorde: ten years and a billion pounds later.. Pluto Press; London:
14 Environmental Studies Board. 1973 Biological impacts of increased intensities of solar ultraviolet radiation. National Academy of Sciences, National Academy of Engineering, Washington, D. C.
15 Gaarder A, Jonsen J, Laland S, Hellem A, Owren P. A. 1961; Adenosine diphosphate in red cells as as factor in the adhesiveness of human blood platelets. Nature 192: 531.
16 Harris H. 1971; Cell fusion and the analysis of malignancy. Proceedings of the Royal Society B 179: 1.
17 Harrison M. J. G, Mitchell J. R. A. 1966; The influence of red blood cells on platelet adhesiveness. Lancet II: 1163.
18 Haslam J. R, Lynham J. A. 1973; Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine. Life Sciences 11: 1143.
19 Haslam R. J, Mills D. C. B. 1967; The adenylate kinase of human plasma, erythrocytes and platelets in relation to the degradation of adenosine diphosphate in plasma. Biochemical Journal 103: 773.
20 Hellem A. J. 1960 The adhesiveness of human platelets in vitro . Scandinavian Journal of Clinical and Laboratory Investigation. 12. 51
21 Maurois A. 1927 La vie de Disraeli, Gallimard. Paris: 208.
22 McLaughlin P. J, Dayhoff M. O. 1972 In: M.O. Dayhoff (ed.) Atlas of protein sequence and structure. National Biomedical Research Fund, Silver Springs, Md. 5, 50.
23 Michel H, Caen J. P, Born G. V. R, Miller R, D’Auriac G. A, Meyer P. 1976 Relation between the inhibition of aggregation and the concentration of cAMP in human and rat platelets. (Accepted for publication in British Journal of Haematology).
24 Mills D. C. B, Roberts G. C. K. 1967; Membrane active drugs and the aggregation of human blood platelets. Nature 213: 35.
25 Mills D. C. B, Smith J. B. 1971; The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3’,5’-cyclic monophosphate in platelets. Biochemical Journal 121: 185.
26 Popper K. 1972. The logic of scientific discovery.. Hutchison; London:
27 Rivers J. P. W, Crawford M. A. 1974; Maternal nutrition and the sex ratio at birth. Nature 252: 298.
28 Rothschild V. 1972 Framework for Government research and development. H. M. Stationery Office (Cmd. 5046) London.
29 Schettler G, Weizel A. 1974. Atherosclerosis III.. Springer; New York:
30 Schmid-Schönbein H, Wells R. E, Goldstone J. 1969; Influence of deformability of human red cells upon blood viscosity. Circulation Research 25: 131.
31 Schmed-Schönbein H, Wells R. E, Schildkraut R. 1969; Microscopy and viscometry of blood flowing under uniform shear rate (rheoscopy). Journal of Applied Physiology 26: 67A.
32 Seeman P. 1973; The membrane actions of anaesthetics and tranquilizers. Pharmacological Review 24: 583.
33 Sinakos Z, Caen J. P. 1967; Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog): a comparative study. Thrombosis et Diathesis Haemorrhagica 17: 99.
34 Stehbens W. E. 1965; Endothelial cell mitosis and permeability. Quarterly Journal of Experimental Physiology 50: 90.
35 The Times. 1975 Risks in the upper atmosphere;. leading article, 19th June.
36 Walton K. W. 1975; Pathogenetic mechanisms in atherosclerosis. American Journal of Cardiology 35: 542.
37 Ward B, Dubos R. 1972. Only One World.. Penguin Books; Harmondsworth:
38 Weiss A. J, Aledorf L. M. 1967; Impaired platelet – connective tissue reaction in man after aspirin ingestion. Lancet II: 495.
39 Wilson A. 1973. The Concorde Fiasco.. Penguin Books; Harmandsworth:
40 Wright H. P, Born G. V. R. 1971. Possible effects of blood flow on the turnover rate of vascular endothelial cells. In: Hartert H, Copley A. L. (eds.) Theoretical and Clinical Haemorheology. 220.
41 Zieve P. D, Greenough W. B. 1969; Adenyl cyclase in human platelets: activity and responsiveness. Biochemical and Biophysical Research Communication 35: 462.