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Thromb Haemost 1976; 35(02): 289-294
DOI: 10.1055/s-0038-1647921
Original Article
Schattauer GmbH

Molecular Variant of Factor VII

Ernest Briët
1   Hemostasis and Thrombosis Research Unit (Div. of Hematology, Dept. of Medicine) University Hospital Leiden, The Netherlands.
,
Emil A. Loeliger
1   Hemostasis and Thrombosis Research Unit (Div. of Hematology, Dept. of Medicine) University Hospital Leiden, The Netherlands.
,
Nico H. van Tilburg
1   Hemostasis and Thrombosis Research Unit (Div. of Hematology, Dept. of Medicine) University Hospital Leiden, The Netherlands.
,
Jan J. Veltkamp
1   Hemostasis and Thrombosis Research Unit (Div. of Hematology, Dept. of Medicine) University Hospital Leiden, The Netherlands.
› Author Affiliations
Further Information

Publication History

Received 26 March 1975

Accepted 03 September 1975

Publication Date:
02 July 2018 (online)

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Summary

Two patients with severe factor VII deficiency appeared to be different with respect to the presence of inactive factor VH-like material in their plasma.

The inactive material, demonstrated in one patient’s plasma and adsorbable onto BaSO4, inhibits the thrombotest-system and is capable of neutralizing a heterologous antibody against factor VII in a fluid phase system.

 

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