The Effect of Antithrombin III on the Activity of the Coagulation Factors VII, IX and X

B Østerud; M Miller-Andersson; U Abildgaard; H Prydz

doi:10.1055/s-0038-1647922

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 35(02): 295-304
DOI: 10.1055/s-0038-1647922

Original Article

Schattauer GmbH

The Effect of Antithrombin III on the Activity of the Coagulation Factors VII, IX and X

B Østerud

¹Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway

,

M Miller-Andersson

¹Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway

,

U Abildgaard

¹Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway

,

H Prydz

¹Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway

› Author Affiliations

Abstract

Summary

Antithrombin III, purified to homogeneity according to Polyacrylamide gel disc electrophoresis and immunoelectrophoresis, inhibited the activity of purified factor IXa and Xa, whereas factor VII was not inhibited either in the active or in the native form.

Antithrombin III is the single most important inhibitor of factor Xa in plasma. Factor Xa does not, however, reduce the activity of antithrombin III against thrombin.

Full Text

References

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