Various Prothrombin Complex Concentrates and their Effect on Coagulation and Fibrinolysis In Vivo

U Hedner; I.M Nilsson; S.-E Bergentz

doi:10.1055/s-0038-1647933

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 35(02): 386-395
DOI: 10.1055/s-0038-1647933

Original Article

Schattauer GmbH

Various Prothrombin Complex Concentrates and their Effect on Coagulation and Fibrinolysis In Vivo

U Hedner

¹Coagulation Laboratory, University of Lund, Allmänna Sjukhuset, Malmö, Sweden

,

I.M Nilsson

¹Coagulation Laboratory, University of Lund, Allmänna Sjukhuset, Malmö, Sweden

,

S.-E Bergentz

¹Coagulation Laboratory, University of Lund, Allmänna Sjukhuset, Malmö, Sweden

› Author Affiliations

Abstract

Summary

Thromboembolic complications occurring in patients treated with factor IX concentrates have been reported. To study the thrombogenicity various types of factor IX concentrates (50 or 100 units F. IX/kg bodyweight) have been infused in dogs. As control albumin was given. The various components of the coagulation and fibrinolytic system have been assayed before the infusion and at various intervals after the end of infusion (0, 1,4 and 24 hrs). Konyne resulted in marked activation of the coagulation process with decrease of platelets, fibrinogen, F. VIII and appearance of FDP and positive ethanol gelation test. Pro thro mplex and Pre-conativ gave no significant changes. Preconativ is prepared without addition of heparin during the procedure.

Full Text

References

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