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Thromb Haemost 1976; 35(02): 403-414
DOI: 10.1055/s-0038-1647935
Original Article
Schattauer GmbH

The Effects of Therapy with Oestriol Succinate and Ethinyl Oestradiol on the Haemostatic Mechanism in Post-Menopausal Women

Terence Davies
1   University Department of Medicine, The General Infirmary, Leeds LSI. 3EX.
,
Gillian Fieldhouse
1   University Department of Medicine, The General Infirmary, Leeds LSI. 3EX.
,
George P. McNicol
1   University Department of Medicine, The General Infirmary, Leeds LSI. 3EX.
› Author Affiliations
Further Information

Publication History

Received 11 August 1975

Accepted 11 September 1975

Publication Date:
02 July 2018 (online)

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Summary

The effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 μg/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.

 

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