Fibrinogen Response to Turpentine and Endotoxin in Busulfan-Treated Rabbits

Samuel I. Rapaport; Ariella Zivelin

doi:10.1055/s-0038-1647967

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 35(03): 692-701
DOI: 10.1055/s-0038-1647967

Original Article

Schattauer GmbH

Fibrinogen Response to Turpentine and Endotoxin in Busulfan-Treated Rabbits

Authors

Samuel I. Rapaport

¹Departments of Medicine, University of Southern California School of Medicine, Los Angeles, California, University of California School of Medicine, San Diego, California, U.S.A.
Ariella Zivelin

¹Departments of Medicine, University of Southern California School of Medicine, Los Angeles, California, University of California School of Medicine, San Diego, California, U.S.A.

Abstract

Summary

The response of the plasma fibrinogen level to the subcutaneous injection of turpentine and to the intravenous injection of endotoxin was measured in normal rabbits and in rabbits made granulocytopenic and thrombocytopenic with busulfan. Plasma fibrinogen levels rose sharply in both normal and busulfan-treated rabbits but to a significantly lesser extent in the latter animals. A statistically significant relation was found between the number of residual granulocytes in busulfan-treated rabbits and the extent of the rise in fibrinogen level after turpentine. As discussed herein, these data are consistent with the hypothesis that material from granulocytes plays a pathophysiologic role in the stimulation of fibrinogen synthesis in inflammation and after tissue trauma.

Full Text

References

References
1 Beisel W. R. 1975. Metabolie response to infection. In: Creger W. P, Coggins C. H, Hancock E. W. (eds.) Annual Review of Medicine: Selected Topics in the Clinical Sciences.. Annual Reviews Inc.; Palo Alto: 9.
2 Goodnight S. H, Rapaport S. I, Zivelin A. 1975; Fibrinogen levels after inflammation or endotoxin in normal and hypophysectomized rats. American Journal of Physiology 228: 1575.
3 Ham T. H, Curtis F. C. 1938; Plasma fibrinogen response in man. Influence of the nutritional state, induced hyperpyrexia, infectious disease and liver damage. Medicine 17: 413.
4 Homburger F. 1945; A plasma fibrinogen-increasing factor obtained from sterile abscesses in dogs. Journal of Clinical Investigation 24: 43.
5 Kampschmidt R. F, Upchurch H. F. 1974; Effect of leukocytic endogenous mediator on plasma fibrinogen and haptoglobin. Proceedings of the Society for Experimental Biology and Medicine 146: 904.
6 Koj A. 1968; The measurement of absolute and relative synthesis rates of fibrinogen in vivo. . Biochemica et Biophysica Acta 165: 97.
7 Lerner R. G, Rapaport S. I, Siemsen J. K, Spitzer J. M. 1968; Disappearance of fibrinogen ¹³¹I after endotoxin; effects of a first and second injection. American Journal of Physiology 214: 532.
8 Logan L. J, Rapaport S. I, Kuefler P. 1973; Failure of heparin, epsilon aminocaproic acid, or both agents to prevent increased fibrinogen levels after endotoxin in rabbits. Proceedings of the Society for Experimental Biology and Medicine 142: 321.
9 Nachman R. L, Weksler B, Ferris B. 1972; Characterization of human platelet vascular permeability-enhancing activity. Journal of Clinical Investigation 51: 549.
10 Pekarek R, Wannemacher P, Powanda M, Abeles F, Mosher D, Dinterman R, Beisel W. 1974; Further evidence that leukocytic endogenous mediator (LEM) is not endotoxin. Life Sciences 14: 1765.
11 Seligsohn U, Alexander N, Rapaport S. I. 1973; a Fibrinogen synthesis in adrenalectomized rabbits. Proceedings of the Society for Experimental Biology and Medicine 142: 824.
12 Seligsohn U, Rapaport S. I, Kuefler P. R. 1973; b Extra-adrenal effect of ACTH on fibrinogen synthesis. American Journal of Physiology 224: 1172.