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Thromb Haemost 1976; 35(02): 447-459
DOI: 10.1055/s-0038-1647977
Original Article
Schattauer GmbH

Chemorheological Studies of the Effect of Heparin on the Course of Coagulation

K. A Overholser   *
1   Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.
,
C. B Baysinger
1   Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.
,
T. R Harris
1   Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.
,
T Deveau
1   Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.
› Author Affiliations
Further Information

Publication History

Received: 27 October 1975

Accepted: 20 November 1975

Publication Date:
02 July 2018 (online)

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Summary

The influence of sodium heparin on viscoelastic change during coagulation was determined in vitro for whole blood samples from ten normal subjects at heparin concentrations ranging from 0 to 1.45 units/(ml whole blood). A four-parameter chemorheological model was used to describe the time course of coagulation as measured by the Weissenberg Rheogoniometer. One parameter compares closely with the whole blood activated partial thromboplastin time, while the other three may be related to the chemical kinetics of clotting.

The chemorheological model and experimental techniques were then tested in a dog preparation. It was found that rheological measurements are more self-consistent than either thrombelastography or the activated partial thromboplastin time for the assay of in vivo heparin in two dogs.

* Address: Box 6173, Station B, Vanderbilt University, Nashville, Tennessee 37235, U. SA.


 

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