Effects of Fasting on Plasma and Platelet-Free Fatty Acids and Platelet Function in Healthy Males

Knut Gjesdal; Arne Nordøy; Harald Wang; Harald Berntsen; Ole D. Mjøs

doi:10.1055/s-0038-1648048

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 36(02): 325-333
DOI: 10.1055/s-0038-1648048

Original Article

Schattauer GmbH

Effects of Fasting on Plasma and Platelet-Free Fatty Acids and Platelet Function in Healthy Males

Knut Gjesdal

¹Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway

,

Arne Nordøy

¹Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway

,

Harald Wang

¹Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway

,

Harald Berntsen

¹Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway

,

Ole D. Mjøs

¹Department of Internal Medicine, Institute of Clinical Medicine, and the Section of Physiology, Institute of Medical Biology, University of Tromsø N-9012 Tromsø, Norway

› Author Affiliations

Abstract

Summary

10 healthy male volunteers fasted for 72 hours. Their plasma concentration of free fatty acid increased more than two-fold, to 1.8 mmol/1. The number of reversible venous “in vivo” platelet aggregates increased significantly (p <0.01); this figure correlated with the concentration of long-chain saturated free fatty acid in plasma (p <0.02). The correlation with the amount of long-chain saturated free fatty acid plus oleic acid (18:1) was even better (p <0.01). Plasma PF-4 concentration increased, suggesting increased platelet release reaction. In spite of the plasma increase, total platelet FFA concentration was reduced and there was a change in the distribution of platelet free fatty acid which correlated with the degree of aggregation.

Full Text

References

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