RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00035024.xml
PDF herunterladen
Thromb Haemost 1976; 36(02): 325-333
DOI: 10.1055/s-0038-1648048
DOI: 10.1055/s-0038-1648048
Original Article
Effects of Fasting on Plasma and Platelet-Free Fatty Acids and Platelet Function in Healthy Males
Weitere Informationen
Publikationsverlauf
Received
27. Oktober 1975
Accepted
30. April 1976
Publikationsdatum:
03. Juli 2018 (online)
Summary
10 healthy male volunteers fasted for 72 hours. Their plasma concentration of free fatty acid increased more than two-fold, to 1.8 mmol/1. The number of reversible venous “in vivo” platelet aggregates increased significantly (p <0.01); this figure correlated with the concentration of long-chain saturated free fatty acid in plasma (p <0.02). The correlation with the amount of long-chain saturated free fatty acid plus oleic acid (18:1) was even better (p <0.01). Plasma PF-4 concentration increased, suggesting increased platelet release reaction. In spite of the plasma increase, total platelet FFA concentration was reduced and there was a change in the distribution of platelet free fatty acid which correlated with the degree of aggregation.
-
References
- 1 Bull B. S, Schneiderman M. A, Brecher G. 1965; Platelet counts with the Coulter Counter. American Journal of Clinical Pathology 44: 678.
- 2 Carlson L. A, Orø L. 1963; Studies on the relationship between the concentration of plasma free fatty acids and glycerol in vivo . Metabolism: Clinical and Experimental 12: 132.
- 3 Christensen N. J. 1974; Plasma norepinephrine and epinephrine in untreated diabetics, during fasting and after insulin administration. Diabetes 23: 1.
- 4 Clayton S, Cross M. J. 1963; The aggregation of blood platelets by catecholamines and by thrombin. Journal of Physiology (Lond.) 169: 82
- 5 Connor W. E, Hoak J. C, Warner E. D. 1963; Massive thrombosis produced by fatty acid infusion. Journal of Clinical Investigation 42: 860.
- 6 Deykin D, Snyder D. 1973; Effect of epinephrine on platelet lipid metabolism. Journal of Laboratory and Clinical Medicine 82: 554.
- 7 Diem K, Lentner C. 1971. Wissenschaftliche Tabellen. Ciba-Geigy AG, Basle; Switzerland.:
- 8 Dole V. P. 1956; A relation between non-esterified fatty acid in plasma and the metabolism of glucose. Journal of Clinical Investigation 180: 150.
- 9 Doumas B. T, Watson W. A, Biggs H. G. 1971; Albumin standards and the measurement of serum albumin with bromcresol green. Clinica Chimica Acta 31: 87.
- 10 Gjesdal K. 1974; Platelet factor 4 (PF-4). An electro-immuno assay for PF-4 in human plasma. Scandinavian Journal of Haematology 13: 232.
- 11 Gordon R. S, Cherkes A. 1956; Unesterified fatty acid in human blood plasma. Journal of Clinical Investigation 35: 206.
- 12 Haslam R. J. 1964; Role of adenosine diphosphate in the aggregation of human blood-platelets by thrombin and by fatty acid. Nature 202: 765.
- 13 Hirsch J, Farquhar J. W, Ahrens E. H, Peterson M. L, Stoffel W. 1960; Studies of adipose tissue in man. A microtechnic for sampling and analysis. American Journal of Clinical Nutrition 8: 499.
- 14 Hoak J. C, Poole J. C. F, Robinson D. S. 1963; Thrombosis associated with mobilization of fatty acids. American Journal of Pathology 43: 987.
- 15 Hoak J. C, Connor W. E, Warner E. D. 1966; Thrombogenic effects of albumin-bound fatty acids. Archives of Pathology 81: 136.
- 16 Jørgensen L, Rowsell H. C, Hovig T, Glynn M. F, Mustard J. F. 1967; Adenosine diphosphate-induced platelet aggregation and myocardial infarction in swine. Laboratory Investigation 17: 616.
- 17 Kerr J. W, Pirrie R, MacAulay I, Bronte-Stewart B. 1965; Platelet-aggregation by phospholipids and free fatty acids. Lancet 1: 1296.
- 18 Kjekshus J. K, Mjøs O. D. 1972; Effect of free fatty acids on myocardial function and metabolism in the ischaemic dog heart. Journal of Clinical Investigation 51: 1767.
- 19 Kjekshus J. K, Mjøs O. D. 1973; Effect of inhibition of lipolysis on infarct size after experimental coronary artery occlusion. Journal of Clinical Investigation 52: 1770.
- 20 Kurien V. A, Oliver M. F. 1966; Serum-free-fatty-acids after acute myocardial infarction and cerebral vascular occlusion. Lancet 2: 122.
- 21 Laurells S. 1956; Plasma free fatty acids in diabetic acidosis and starvation. Scandinavian Journal of Clinical and Laboratory Investigation 8: 81.
- 22 Laurell S, Lindqvist A. 1971; Fatty acid patterns determined simultaneously in human adipose tissue, liver and plasma during starvation. Scandinavian Journal of Clinical and Laboratory Investigation 27: 29.
- 23 Mahadevan V, Singh H, Lundberg W. O. 1966; Effects of saturated and unsaturated fatty acids on blood platelet aggregation in vitro . Proceedings of the Society for Experimental Biology and Medicine 121: 82.
- 24 Mills D. C. B, Robb I. A, Roberts G. C. K. 1968; The release of nucleotides, 5-hydroxytryp-tamine and enzymes from human blood platelets during aggregation. Journal of Physiology 195: 715.
- 25 Mürer E. H. 1968; Release reaction and energy metabolism in blood platelets with special reference to the burst in oxygen uptake. Biochimica et Biophysica Acta 162: 320.
- 26 Niewiarowski S, Lipinski B, Farbiszewski R, Poplawski A. 1968; The release of platelet factor 4 during platelet aggregation and the possible significance of this reaction in hemostasis. Experientia 24: 343.
- 27 Nordøy A. (1973/74): Plasma and platelet lipids in man. Haemostasis 2: 103.
- 28 Nordøy A, Strøm E, Gjesdal K. 1974; The effect of alimentary hyperlipaemia and primary hypertriglyceridaemia on platelets in man. Scandinavian Journal of Haematology 12: 329.
- 29 Nordøy A, Gjesdal K, Berntsen H. 1975; The effect of noradrenalin infusion on plasma and platelet lipids and platelet function in man. Thrombosis et Diathesis Haemorrhagica 33: 328.
- 30 O’Brien J. R. 1963; Some effects of adrenaline and anti-adrenaline compounds on platelets in vitro and in vivo . Nature 200: 763.
- 31 Reimers H. J, Packham M. A, Kinlough-Rathbone R. L, Mustard J. F. 1973; Effect of treatment of rabbit platelets with low concentration of thrombin on their function, metabolism and survival. British Journal of Haematology 25: 675.
- 32 Renaud S, Gautheron P. (1973/74): Dietary fats and experimental (cardiac and venous) thrombosis. Haemostasis 2: 53.
- 33 Shore P. A, Alpers H. S. 1963; Platelet damage induced in plasma by certain fatty acids. Nature 200: 1331.
- 34 Snedecor G. W, Cochran W. G. 1967. Statistical Methods. 6. Iowa State University Press; Ames, Iowa, USA.:
- 35 Spector A. A, Hoak J. C, Warner E. D, Fry G. L. 1970; Utilization of long-chain free fatty acids by human platelets. Journal of Clinical Investigation 49: 1489.
- 36 Taggart P, Carruthers M. 1971; Endogenous hyperlipidaemia induced by emotional stress of racing driving. Lancet 1: 363.
- 37 Trout D. L, Estes E. H, Friedberg S. J. 1969; Titration of free fatty acids of plasma: a study of current methods and a new modification. Journal of Lipid Research 1: 199.
- 38 Werner W, Rey H.-G, Wielinger H. 1970; Über die Eigenschaften eines neuen Chromogens für die Blutzuckerbestimmung nach der GOD/POD-Methode. Zeitschrift für Analytische Chemie 252: 224.
- 39 Wu K. K, Hoak J. C. 1974; A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency. Lancet 2: 924.
- 40 Youssef A, Barkhan P. 1968; Release of platelet factor 4 by adenosine diphosphate and other platelet aggregating agents. British Medical Journal 1: 746.
- 41 Zbinden G. 1964; Transient thrombopenia after intravenous injection of certain fatty acids. Journal of Lipid Research 5: 378.