Physico-Chemical Explanation of Blood Cell Adhesion in Thrombus Formation

A Marmur; E Ruckenstein; S. R Rakower

doi:10.1055/s-0038-1648058

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 36(02): 430-440
DOI: 10.1055/s-0038-1648058

Original Article

Schattauer GmbH

Physico-Chemical Explanation of Blood Cell Adhesion in Thrombus Formation

A Marmur^*

¹Faculty of Engineering and Applied Sciences, and the Department of Surgery, School of Medicine, State University of New York at Buffalo, Buffalo, NY 14214

²The Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA

,

E Ruckenstein

¹Faculty of Engineering and Applied Sciences, and the Department of Surgery, School of Medicine, State University of New York at Buffalo, Buffalo, NY 14214

²The Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA

,

S. R Rakower

¹Faculty of Engineering and Applied Sciences, and the Department of Surgery, School of Medicine, State University of New York at Buffalo, Buffalo, NY 14214

²The Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA

› Author Affiliations

Abstract

Summary

A model is suggested which assumes that the rate of deposition of cells is determined both by hydrodynamic factors and by Brownian motion over the potential barrier caused by London and double-layer forces in the immediate vicinity of the deposition surface. The height of the barrier in the potential energy of interaction between blood cells and various surfaces is analyzed in relation to the physical properties of the cells, surfaces, and solutions. Based on this analysis, the adhesion of platelets to injured blood vessel walls and to non-biologic materials, the lack of adhesion of red blood cells under the same conditions, the mechanism of ADP induced aggregation and the interaction with blood flow are explained. The qualitative predictions of the model are substantiated by available experimental information. Quantitative results are presented in terms of a time constant, which typifies a period of contact with a surface, during which appreciable deposition occurs.

Full Text

References

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