Plasma Factor XIII and Platelet Factor XIII in Hyperlipaemia

Mircea P. Cucuianu; K Miloszewski; D Porutiu; M. S Losowsky

doi:10.1055/s-0038-1648075

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1976; 36(03): 542-550
DOI: 10.1055/s-0038-1648075

Original Article

Schattauer GmbH

Plasma Factor XIII and Platelet Factor XIII in Hyperlipaemia

Mircea P. Cucuianu

¹Medical Clinic N.I., Cluj — Napoca, Rumania

²Department of Medicine, St. James’s University Hospital, Leeds LS9 7TF, England

,

K Miloszewski

¹Medical Clinic N.I., Cluj — Napoca, Rumania

²Department of Medicine, St. James’s University Hospital, Leeds LS9 7TF, England

,

D Porutiu

¹Medical Clinic N.I., Cluj — Napoca, Rumania

²Department of Medicine, St. James’s University Hospital, Leeds LS9 7TF, England

,

M. S Losowsky

¹Medical Clinic N.I., Cluj — Napoca, Rumania

²Department of Medicine, St. James’s University Hospital, Leeds LS9 7TF, England

› Institutsangaben

Abstract

Summary

Plasma factor XIII activity measured by a quantitative assay was found to be significantly higher in hypertriglyceridaemic patients (type IV and combined hyperlipoproteinaemia), as compared to normolipaemic controls. No such elevation in plasma factor XIII activity was found in patients with type IIa hyperlipaemia. Plasma pseudocholinesterase was found to parallel the elevated factor XIII activity in hypertriglyceridaemic subjects.

In contrast, platelet factor XIII activity was not raised in hyperlipaemic subjects, and plasma factor XIII was found to be normal in a normolipaemic subject with throm-bocythaemia.

It was concluded that there is no significant contribution from platelets to plasma factor XIII activity, and that the observed increase in plasma factor XII in hypertriglyceridaemia results from enhanced hepatic synthesis of the enzyme.

Volltext

Referenzen

References
1 Akanuma Y, Kuzuya T, Hayashi M, Ide T, Kuzuya N. 1973; Positive correlation of serum lecithin: cholesterol acyltransferase activity with relative body-weight. European Journal of Clinical Investigation 3: 136.
2 Astrup T, Brakman P, Nissen U. 1965; The estimation of fibrinogen. A revision. Scandinavian Journal of Clinical Laboratory Investigation 17: 57.
3 Bohn N, Haupt H. 1968; Eine quantitative Bestimmung von Faktor XIII mit Anti-Faktor-XIII-Serum. Thrombosis et Diathesis Haemorrhagica 19: 309.
4 Brecher G, Cronkhe E. P. 1950; Morphology and enumeration of human blood platelets. Journal of Applied Physiology 3: 365.
5 Carvalho A, Colman R. W, Lees R. S. 1974; Platelet function in hyperlipoproteinemia. New England Journal of Medicine 290: 434.
6 Cucuianu M. P, Vasile V. A, Popescu T. A, Opincaru A, Crisnic I, Tapalaga D. 1973; a Clinical studies concerning factor XIII: with special reference to hyperlipemia. Thrombosis et Diathesis Haemorrhagica 30: 480.
7 Cucuianu M, Deac M, Bornuz F, Macavei I. 1973; b Effect of L-asparaginase therapy upon some indices of protein metabolism in leukemic patients. Revue Romaine de Medecine Interne 10: 121.
8 Cucuianu M, Popescu T. A, Opincaru A, Haragus S. 1975; Serum pseudocholinesterase and ceruloplasmin in various types of hyperlipoproteinemia. Clinica Chimica Acta 59: 19.
9 de la Huerga J, Yesinick C, Popper H. 1952; Colorimetric method for the determination of serum cholinesterase. American Journal of Clinical Pathology 22: 1126.
10 Dvilansky A, Britten A. F. H, Loewy A. G. 1970; Factor XIII assay by an isotope method. I. Factor XIII (transamidase) in plasma, serum, leukocytes, erythrocytes and platelets and evaluation of screening tests of clot solubility. British Journal of Haematology 18: 399.
11 Heene D. L. 1968; Diskussion: Bestimmungsmethoden von Faktor XIII. In: Deutsch E. (ed.): Fibrinstabilisierenden Faktor, Struktur des Blutgerinnsels, Krebs und Blutgerinnung. Verhandlungen der Deutschen Arbeitsgemeinschaft für Blutgerinnung. Wien 14–15th April 1967. Thrombosis et Diathesis Haemorrhagica Suppl 28: 23.
12 Heene D. L. 1969 Gerinnungsanalytische Untersuchungen zum Verhalten des fibrinstabilisierenden Faktors bei Aktivierung des Gerinnungs- und Fibrinolyse-Systems. Ein Beitrag zur Diagnostik und Genese des erworbenen Mangels an fibrinilisierendem Faktor. Habilitationsschrift zur Erlangung der Venia Legendi an der Medizinischen Fakultät der Justus Liebig-Universität Gießen..
13 Idu S. M, Cociumian L. 1971; Electrophoreogram estimation of plasma lipoproteins separated in agarose gel. Revue Roumaine de Biochimie 8: 219.
14 Jonker J. J. C, Veen M. R, Schopman W, den Ottolander G. J. G. 1974; Platelet survival time in angina pectoris and hyperlipoproteinemia In: Nordoy, A. Jorgensen L. and Prydz, H. (Eds): Lipids and Thrombosis. Proceedings of the IIIrd Tromso Seminar in Medicine. University of Tromso, Norway, June 20–22nd 1974. Thrombosis Research 4 Suppl. v. 81.
15 Kiesselbach T. H, Wagner R. A. 1966; Fibrin stabilizing factor: a thrombin labile platelet protein. American Journal of Physiology 211: 1472.
16 Letheby B. A, Davis R. A, Larsen A. E. 1974; The effect of major surgical procedures on plasma and platelet Factor XIII. Thrombosis Diathesis Haemorrhagica 31: 26.
17 Losowsky M. S, Hall R, Goldie W. 1965; Congenital deficiency of fibrin stabilising factor. Lancet II: 156.
18 McDonagh J, Kiesselbach T. H, Wagner R. H. 1969; Factor XIII and antiplasmin activity in human platelets. American Journal of Physiology 216: 508.
19 Martin P. J, Martin J. V, Goldenberg D. M. 1975; Gamma-glutamyl transpeptidase, triglycerides and enzyme induction. British Medical Journal 1: 17.
20 Moga A, Cucuianu M, Crisnic I, Olinic N. 1966; Platelet adhesiveness during different evolutive stages of atherosclerosis; correlations with serum lipids. Revue Roumaine de Medecine Interne 3: 407.
21 Noble R. P. 1968; Electrophoretic separation of plasma lipoproteins in agarose gel. Journal of Lipid Research 9: 693.
22 Ottaviani P, Mandelli F, Fontana L, Morelli R. C. 1965; Comportamento del fattore stabilizante fibrinico nelle epatopatie. Il Progresso Medico 21: 115.
23 Scrobohaci M, Stancioiu N, Stefanescu N, Idu S. 1975 Platelet Factor XIII in hyperlipidemias. Vth Congress of the International Society of Thrombosis and Haemostasis, Paris 21st-26th July 1975. Abstract 355.
24 Sheltawy M. J, Miloszewski K, Losowsky M. S. 1972; Factors affecting factor XIII assay by dansyl cadaverine incorporation. Thrombosis et Diathesis Haemorrhagica 28: 483.
25 Sullivan J. M, Heinle R. A, Gorlin R. 1972; Studies of platelet adhesiveness, glucose tolerance and serum lipoprotein patterns in pateints with coronary artery disease. American Journal of the Medical Sciences 264: 475.
26 Van Handel E, Zilversmit D. B. 1957; Micromethod for the direct determination of serum triglyceride. Journal of Laboratory and Clinical Medicine 50: 152.
27 Walls W. D, Losowsky M. S. 1969; Plasma fibrin stabilising factor (FSF) in normal subjects and patients with chronic liver disease. Thrombosis et Diathesis Haemorrhagica 21: 134.
28 Zahavi I, Dreyfuss F. 1969; An abnormal pattern of ADP induced platelet aggregation in acute myocardial infarction. Thrombosis et Diathesis Haemorrhagica 21: 76.
29 Zlatkis A, Zak B, Boyle A. J. 1953; A new method for the direct determination of serum cholesterol. Journal of Laboratory and Clinical Medicine 41: 486.
30 Zöllner N, Kirsch K. 1962; Über die quantitative Bestimmung von Lipiden (Micromethode) mittels der vielen natürlichen Lipoide (allen bekannten Plasmalipoiden) gemeinsamen sulphonphos-phovanilin Reaktion. Zeitschrift für die gesamte experimentelle Medizin 135: 545.