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Thromb Haemost 1973; 29(03): 661-670
DOI: 10.1055/s-0038-1648108
Original Article
Schattauer GmbH

A Simple Indirect Method to Evaluate Platelet

Aggregation The Clot Retraction Inhibition (CRI) Test
G de Gaetano
1   Laboratory of Blood Coagulation, Department of Internal Medicine, University of Leuven, Belgium
,
J Vermylen
1   Laboratory of Blood Coagulation, Department of Internal Medicine, University of Leuven, Belgium
,
M Verstraete
1   Laboratory of Blood Coagulation, Department of Internal Medicine, University of Leuven, Belgium
› Author Affiliations
Further Information

Publication History

Publication Date:
30 June 2018 (online)

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Summary

A simple indirect method to evaluate platelet aggregation is described: the Clot Retraction Inhibition (CRI)-test, based on the observation that clot retraction is inhibited by previous in vitro platelet aggregation ; a highly significant correlation exists between the inhibition of clot retraction and each of the three parameters of aggregation curves which have been evaluated by turbidometry.

The CRI-test is more sensitive in certain circumstances (thrombocytopenia, hyperlipaemia, contamination with red or white cells), than turbidometry.

The CRI-test can also be satisfactorily performed on citrated total blood.

 

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