Lipid Infusions in Man

K. A Grøttum; A Nordøy; A Hellem

doi:10.1055/s-0038-1648113

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(03): 701-711
DOI: 10.1055/s-0038-1648113

Original Article

Schattauer GmbH

Lipid Infusions in Man

Blood Platelet Uptake of Lipid and Effects on Platelet Functions

Authors

K. A Grøttum

¹Section of Haematology (Chief, Professor P. F. Hjort), Medical Department A (Chief, Professor E. Gjone): Institute for Thrombosis Research (Chief, Professor H. Stormorken), Rikshospitalet, Oslo, Norway
A Nordøy

¹Section of Haematology (Chief, Professor P. F. Hjort), Medical Department A (Chief, Professor E. Gjone): Institute for Thrombosis Research (Chief, Professor H. Stormorken), Rikshospitalet, Oslo, Norway
A Hellem

¹Section of Haematology (Chief, Professor P. F. Hjort), Medical Department A (Chief, Professor E. Gjone): Institute for Thrombosis Research (Chief, Professor H. Stormorken), Rikshospitalet, Oslo, Norway

Abstract

Summary

The soybean lipid emulsion Intralipid was infused during two hours in 13 volunteer individuals. Biochemically, lipid infusions increased the platelet content of triglycerides, but did not cause significant platelet aggregation, and the platelet counts and survival time were unchanged. However, the lipid infusions reduced platelet and erythrocyte electrophoric mobility, reduced the availability of platelet factor 3 by ADP or kaolin and reduced platelet adhesiveness. A coating of parts of the platelet surface by lipid particles or some other changes in the platelet membrane could explain the effects on platelet electrophoretic mobility, platelet factor 3, and adhesiveness.

Full Text

References

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