Immunological Detection of Activated Platelets in Clinical Disorders

• References

• 1 Fitzgerald DJ, Roy L, Catella F, Fitzgerald GA. Platelet activation in unstable coronary disease. New Engl J Med 1986; 315: 983-989
• 2 Hamm CW, Lorenz RL, Bleifeld W, Kupper W, Wober W, Weber PC. Biochemical evidence of platelet activation in patients with persistent unstable angina. J Am Coll Cardiol 1987; 10: 998-1006
• 3 Fuster V, Chesebro JH. Antithrombotic therapy: Role of platelet inhibitor drugs. I. Thrombogenesis: role of platelets. Mayo Clin Proc 1981; 56: 102-112
• 4 Fitzgerald DJ, Wright F, FitzGerald GA. Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the reponse to tissue-type plasminogen activator in vivo. Circ Res 1989; 65: 83-94
• 5 Reilly IAG, Roy L, FitzGerald GA. Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud’s phenomenon. Br Med J 1986; 292: 1037
• 6 Reilly IAG, Doran JB, Smith G, FitzGerald GA. Increased thromboxane biosynthesis in a human preparation of platelet activation: Biochemical and functional consequences of selective inhibition of thromboxane synthase. Circulation 1986; 73: 1300-1309
• 7 Fitzgerald DJ, Catella F, Roy L, FitzGerald GA. Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction. Circulation 1988; 77: 142-150
• 8 Levine SP. Secreted platelet proteins as markers for pathological disorders. In: Biochemistry of Platelets Phillips DR, Shuman MA. (eds) Academic Press; New York: 1986. pp 377-415
• 9 Catella F, Healy D, Lawson JA, FitzGerald GA. 11-Dehydrothromboxane B 2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 1986; 83: 5861-5865
• 10 van Oost B, Hien-Hag IHV, Ans PM, Timmermans PM, Sixma JJ. The effect of thrombin on the density distribution of blood platelets: Detection of activated platelets in the circulation. Blood 1983; 62: 433-440
• 11 Shattil SJ, Hoxie JA, Cunningham M, Brass LF. Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J Biol Chem 1985; 260: 11107-11114
• 12 Sims PJ, Cunningham M, Shattil SJ. Effect of platelet activation on the conformation of the glycoprotein IIb-IIIa complex. Circulatio 1990; 82 III 369
• 13 Woods VL, Wolff LE, Keller DM. Resting platelets contain a substantial centrally located pool of glycoprotein IIb-IIIa complex which may be accessible to some but not other extracellular proteins. J Biol Chem 1986; 261: 15242
• 14 Plow EF, Ginsberg MH. Cellular adhesion: GP IIb-IIIa as a prototype adhesion receptor. Prog Haemostas Thromb 1989; 9: 117-156
• 15 Bennett JS, Shattil SJ, Power JW, Gartner TK. Interaction of fibrinogen with its platelet receptor. Differential aspects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex. J Biol Chem 1988; 263: 12948-12953
• 16 Taub R, Gould RJ, Garsky VM, Ciccarone TM, Hoxie J, Friedman PA, Shattil SJ. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem 1989; 264: 259-265
• 17 Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood 1986; 68: 1224-1231
• 18 Tomiyama Y, Tsubakio T, Piotrowicz RS, Kurata Y, Kunicki U. An activation-dependent conformational change in the platelet membrane glycoprotein IIb-IIIa complex evidenced by the RGD-depen-dent binding of the murine monoclonal antibody OP-G2. Blood 1990 76. 479a
• 19 Warkentin TE, Powling MJ, Hardisty RM. Measurement of fibrinogen binding to platelets in whole blood by flow cytometry: A micromethod for the detection of platelet activation. Br J Haematol 1990; 76: 387-394
• 20 Shattil SJ, Budzynski A, Scrutton MC. Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. Blood 1989; 73: 150-158
• 21 Abrams CS, Ellison N, Budzynski AZ, Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood 1990; 75: 128-138
• 22 Zamarron C, Ginsberg MH, Plow EF. Monoclonal antibodies specific for a conformationally altered state of fibrinogen. Thromb Haemostas 1990; 64: 41-46
• 23 Zamarron C, Ginsberg MH, Plow EF. Receptor-induced binding sites (RIBS) are exposed in fibrinogen as a consequence of its interaction with platelets. Blood 1989 74. 208a
• 24 Ginsberg MH, Frelinger AL, Lam SC-T, Forsyth J, McMillan R, Plow EF, Shattil SJ. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood 1990; 76: 2017-2023
• 25 Frelinger AL III, Lam SC-T, Plow EF, Smith MA, Loftus JC, Ginsberg MH. Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. J Biol Chem 1988; 263: 12397-12402
• 26 Frelinger AL III, Cohen I, Plow EF, Smith MA, Roberts J, Lam SC-T, Ginsberg MH. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem 1990; 265: 6346-6352
• 27 Stenberg PE, Bainton DF. Storage organelles in platelets and megakaryocytes. In: Biochemistry of Platelets Phillips DR, Shuman MA. (eds) Academic Press; New York: 1986. pp 257-295
• 28 Hsu-Lin SC, Berman CL, Furie BC, August D, Furie B. A platelet membrane protein expressed during platelet activation. J Biol Chem 1984; 259: 9121-9126
• 29 McEver RP, Martin NM. A monclonal antibody to a membrane glycoprotein binds only to activated platelets. J Biol Chem 1984; 259: 9799-9804
• 30 Johnston GI, Cook RG, McEver RP. Cloning of GMP-140, a granule membrane protein of platelets and endothelium: Sequence similarity to proteins involved in cell adhesion and inflammation. Cell 1989; 56: 1033-1044
• 31 Larsen E, Celi A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie B. PAD GEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 1989; 59: 305-312
• 32 Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood 1990; 75: 550-554
• 33 Larsen E, Palabrica T, Sajer S, Gilbert GE, Wagner DD, Furie BC, Furie B. PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Cell 1990; 63: 467-474
• 34 Febbraio M, Silverstein RL. Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. J Biol Chem 1990; 256: 18531-18537
• 35 Silverstein RL, Febbraio M. LAMP-2 is an activation-dependent platelet surface protein: Further evidence for platelet lysosomal membrane flow. J Cell Biol 1990 111. 66a
• 36 Nieuwenhuis HK, van Ouosterhout JJG, Rozemuller E, van Iwaarden F, Sixma JJ. Studies with a monoclonal antibody against activated platelets. Evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in the circulation. Blood 1987; 70: 838-845
• 37 Metzelaar MJ, Sixma JJ, Nieuwenhuis HK. Detection of platelet activation using activation specific monoclonal antibodies. Blood Cells 1990; 16: 85-93
• 38 Metzelaar MJ, Wijngaard PJ, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC. CD63 Antigen. A novel lysosomal membrane glycoprotein cloned by a screening procedure for intracellular antigens in eukaryotic cells. J Biol Chem 1991; 266: 3239-3245
• 39 Gerrard JM, Lint D, Sims PJ, Wiedmer T, Fugate D, McMillan E, Roberts C, Israels SJ. Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome. Blood 1991; 77: 101-112
• 40 Aiken ML, Ginsberg MH, Plow EF. Mechanisms for expression of thrombospondin on the platelet cell surface. Semin Thromb Hemostas 1987; 13: 307-316
• 41 Boukerche H, McGregor JL. Characterization of an anti-thrombo-spondin monoclonal antibody (P8) that inhibits human platelet functions. Eur J Biochem 1988; 171: 383-392
• 42 Capitanio AM, Niewiarowski S, Rucinski B, Tuszynski GP, Cier-niewski CS, Hershock D, Komecki E. Interaction of platelet factor 4 with human platelets. Biochim Biophys Acta 1985; 839: 161-173
• 43 Adelman B, Carlson P, Powers P. von Willebrand factor binds to stimulated platelets in plasma. Blood 1987; 70: 1362-1369
• 44 Ruggeri ZM. Functional domains of von Willebrand factor involved in interactions with platelets and the subendothelium. Prog Clin Biol Res 1988; 283: 219-253
• 45 Lam SC, Plow EF, D’Souza SE, Cheresh DA, Frelinger AL 3d, Ginsberg MH. Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. J Biol Chem 1989; 264: 3742-3749
• 46 McGregor JL, Catimel B, Parmentier S, Clezardin P, Dechavanne M, Leung LLK. Rapid purification and partial characterization of human platelet glycoprotein IIIb. Interaction with thrombospondin and its role in platelet aggregation. J Biol Chem 1989; 264: 501-506
• 47 Leung LLK, Nachman RL. Complex formation of platelet thrombospondin with fibrinogen. J Clin Invest 1982; 70: 542-549
• 48 Silverstein RL, Asch AS, Nachman RL. Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. J Clin Invest 1989; 84: 546-552
• 49 Mann KG, Nesheim ME, Church WR, Haley P, Krishnaswamy S. Surface-dependent reactions of the vitamin K-dependent enzyme complexes. Blood 1990; 76: 1-16
• 50 Nesheim ME. The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets. J Biol Chem 1988; 263: 16467-16470
• 51 Sims PJ, Faioni EM, Wiedmer T, Shattil SJ. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem 1989; 263: 18205-18212
• 52 Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ. Relationship between the binding sites for factors VIII and Va on platelets, platelet-derived microparticles, and phospholipid vesicles. Blood 1989 74. 36a
• 53 Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monclonal antibodies and flow cytometry. Blood 1987; 70: 307-315
• 54 Montgomery RR, Kunicki TJ, Taves C, Pidard D, Corcoran M. Diagnosis of Bemard-Soulier syndrome and Glanzmann’s thrombasthenia with a monoclonal antibody in whole blood. J Clin Invest 1983; 71: 385-389
• 55 Hourdille P, Heilmann E, Combrie R, Winckler J, Clemetson KJ, Nurden AT. Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets. Blood 1990; 76: 1503-1513
• 56 Michelson AD, Barnard MR. Thrombin-induced changes in platelet membrane glycoproteins lb, IX, and Ilb-IIIa complex. Blood 1987; 70: 1673-1678
• 57 Hamilton KK, Hattori R, Esmon CT, Sims PJ. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. J Biol Chem 1990; 265: 3809-3814
• 58 George JN, Pickett EB, Saucerman S, McEver RP, Kunicki TJ, Kieffer N, Newman PJ. Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery. J Clin Invest 1986; 40-348
• 59 Morrison SA. Origin of a fluorescence increase accompanying the limited proteolysis of fluorescein-labeled human prothrombin by Factor Xa. Int J Pept Protein Res 1984; 24: 377-385
• 60 Johnston GI, Pickett EB, McEver RP, George JN. Heterogeneity of platelet secretion in response to thrombin demonstrated by floures-cence flow cytometry. Blood 1987; 69: 1401-1403
• 61 Marti GE, Magruder L, Schuette WE, Gralnick HR. Flow cytometric analysis of platelet surface antigens. Cytometry 1988; 9: 448-455
• 62 Fabris F, Casonato A, Randi ML, Luzzatto G, De Silvestro G, Ongaro G, Girolami A. The use of fluorescence flow cytometry in the characterization of Bemard-Soulier Syndrome and Glanzmann’s thrombasthenia. Haematologica (Pavia) 1989; 74: 39-44
• 63 Loftus JC, O’Toole TE, Plow EF, Glass A, Frelinger AL, Ginsberg MH. A β3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 1990; 249: 915-918
• 64 Fournier DJ, Kabral A, Castaldi PA, Berndt MC. A variant of Glanzmann’s thrombastenia characterized by abnormal glycoprotein Ilb/IIIa complex formation. Thromb Haemostas 1989; 62: 977-983
• 24 Tomer A, Stahl RL, Harker LA. Decreased platelet membrane glycoprotein (GP) Ilb-IIIa receptor expression and activation in primary thrombocytosis. Blood 1990 76. 479a
• 66 Schafer AI. Essential thrombocythemia. Prog Hemost Thromb 1990; 10: 69-96
• 67 George JN, Shattil SJ. The clinical importance of acquired abnormalities of platelet function. New Engl J Med 1991; 324: 27-39
• 68 Lages B, Shattil SJ, Bainton D, Weiss HJ. Decreased content and surface expression of alpha-granule membrane protein GMP-140 in one of two types of platelet alpha-delta storage pool deficiency. J Clin Invest 1991; 87: 919-929
• 69 Rosa JP, George JN, Bainton DF, Nurden AT, Caen JP, McEver RP. Gray platelet syndrome. Demonstration of alpha granule membranes that can fuse with the cell surface. J Clin Invest 1987; 80: 1138-1146
• 70 Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: An isolated defect in platelet procoagulant activity. J Biol Chem 1989; 264: 17049-17057
• 71 Lages B, Weiss HJ. Heterogeneous defects of platelet secretion and responses to weak agonists in patients with bleeding disorders. Br J Haematol 1988; 68: 53-62
• 72 Davies TA, Drotts D, Weil GJ, Simons ER. Flow cytometric measurements of cytoplasmic calcium changes in human platelets. Cytometry 1988; 9: 138-142
• 73 Merritt JE, McCarthy SA, Davies MP, Moores KE. Use of fluo-3 to measure cytosolic Ca2+ in platelets and neutrophils. Loading cells with the dye, calibration of traces, measurements in the presence of plasma, and buffering of cytosolic Ca2+. Biochem J 1990; 269: 513-519
• 74 Tschoepe D, Spangenberg P, Esser J, Schwippert B, Kehrel B, Roesen P, Gries FA. Flow-cytometric detection of surface membrane alterations and concomitant changes in the cytoskeletal actin status of activated platelets. Cytometry 1990; 11: 652-656
• 75 Woodman HC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood 1990; 76: 1680-1697
• 76 Corash L. Measurements of platelet activation by fluorescence-activated flow cytometry. Blood Cells 1990; 16: 97-106
• 77 Scharf RE, Tomer A, Tierstein P, Ruggeri ZM, Harker LA. Flow cytometric analysis of activated circulating platelets during percutaneous transluminal coronary angioplasty. Blood 1989 74. 32a
• 78 George JN, Pickett EB, Heinz R. Platelet membrane glycoprotein changes during the preparation and storage of platelet concentrates. Transfusion 1988; 28: 123-126
• 79 Rinder H, Murphy M, Ault KA, Stocks J, Slichter S, Hillman RS. Quantitation of platelet activation during storage: Evidence that activated platelets fail to circulate following transfusion. Blood 1988 72. 283a
• 80 Schullek J, Jordon J, Montogomery RR. Interaction of von Willebrand factor with human platelets in the plasma millieu. J Clin Invest 1984; 72: 421-428