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Thromb Haemost 1992; 67(01): 060-062
DOI: 10.1055/s-0038-1648380
Original Articles
Schattauer GmbH Stuttgart

Presence and Possible Origin of ɛ(γ-Glutamyl)Lysine Isodipeptide in Human Plasma

J Harsfalvi
Department of Biochemistry, University School of Medicine, Debrecen
,
E Tarcsa
*   The 2nd Department of Medicine, University School of Medicine, Debrecen
,
M Udvardy
Department of Biochemistry, University School of Medicine, Debrecen
,
G Zajka
#   Institute of lsotopes, Hungarian Academy of science, Budapest, Hungary
,
T Szarvas
#   Institute of lsotopes, Hungarian Academy of science, Budapest, Hungary
,
L Fesus
*   The 2nd Department of Medicine, University School of Medicine, Debrecen
› Author Affiliations
Further Information

Publication History

Received 15 May 1991

Accepted after revision 15 August 1991

Publication Date:
02 July 2018 (online)

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Summary

ɛ(γ-glutamyl)lysine isodipeptide has been detected in normal human plasma by a sensitive HPLC technique in a concentration of 1.9-3.6 μmol/1. Incubation of in vitro clotted plasma at 37° C for 12 h resulted in an increased amount of isodipeptide, and there was no further significant change when streptokinase was also present. Increased in vivo isodipeptide concentrations were also observed in hypercoagulable states and during fibrinolytic therapy.

 

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