Presence and Possible Origin of ɛ(γ-Glutamyl)Lysine Isodipeptide in Human Plasma

J Harsfalvi; E Tarcsa; M Udvardy; G Zajka; T Szarvas; L Fesus

doi:10.1055/s-0038-1648380

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1992; 67(01): 060-062
DOI: 10.1055/s-0038-1648380

Original Articles

Schattauer GmbH Stuttgart

Presence and Possible Origin of ɛ(γ-Glutamyl)Lysine Isodipeptide in Human Plasma

J Harsfalvi

Department of Biochemistry, University School of Medicine, Debrecen

,

E Tarcsa

^*The 2nd Department of Medicine, University School of Medicine, Debrecen

,

M Udvardy

Department of Biochemistry, University School of Medicine, Debrecen

,

G Zajka

^#Institute of lsotopes, Hungarian Academy of science, Budapest, Hungary

,

T Szarvas

^#Institute of lsotopes, Hungarian Academy of science, Budapest, Hungary

,

L Fesus

^*The 2nd Department of Medicine, University School of Medicine, Debrecen

› Author Affiliations

Abstract

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Summary

ɛ(γ-glutamyl)lysine isodipeptide has been detected in normal human plasma by a sensitive HPLC technique in a concentration of 1.9-3.6 μmol/1. Incubation of in vitro clotted plasma at 37° C for 12 h resulted in an increased amount of isodipeptide, and there was no further significant change when streptokinase was also present. Increased in vivo isodipeptide concentrations were also observed in hypercoagulable states and during fibrinolytic therapy.

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References

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