Subunit Composition of Plasma von Willebrand Factor (vWF) in Two Uremic Patients with Acquired vWF Abnormalities

Thromb Haemost 1992; 67(01): 183
DOI: 10.1055/s-0038-1648405

Letters to the Editor

Schattauer GmbH Stuttgart

Giancarlo Castaman

Department of Hematology and Hemophilia and Thrombosis Centre, San Bortolo Hospital, Vicenza, Italy

,

Francesco Rodeghiero

Department of Hematology and Hemophilia and Thrombosis Centre, San Bortolo Hospital, Vicenza, Italy

,

Antonella Lattuada

Department of Hematology and Hemophilia and Thrombosis Centre, San Bortolo Hospital, Vicenza, Italy

,

Pier Mannuccio Mannucci

Department of Hematology and Hemophilia and Thrombosis Centre, San Bortolo Hospital, Vicenza, Italy

,

A Bianchi Bonomi

Hemophilia Centre and Institute of Internal Medicine, University of Milan, Milan, Italy

References
1 Rodeghiero F, Castaman G, Lombardi R, Mannucci PM. Von Willebrand factor abnormalities in two patients with uraemia. Lancet 1988; ii: 1016-1017
2 Hoyer LW, Rizza CR, Tuddenham EGD, Carta CA, Armitage H, Rotblat F. Von Willebrand factor multimer pattern in von Willebrand’s disease. Br J Haematol 1983; 55: 493-507
3 Mannucci PM, Lombardi R, Castaman G, Dent JA, Lattuada A, Rodeghiero F, Zimmerman TS. Von Willebrand disease “Vicenza” with larger-than-normal (supranormal) von Willebrand factor multi-mers. Blood 1988; 71: 65-70
4 Zimmermann TS, Dent JA, Ruggeri ZM, Nannini LH. Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers. J Clin Invest 1986; 77: 947-951
5 Moake JL, Rudy CK, Troll JH, Weinstein MJ, Colannino NM, Azocar J, Seder RH, Hong SL, Deykin D. Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med 1982; 307: 1432-1435