Download PDF
Thromb Haemost 1992; 67(06): 623-626
DOI: 10.1055/s-0038-1648512
Original Articles
Schattauer GmbH Stuttgart

Tumor Necrosis Factor Induces von Willebrand Factor Release in Healthy Humans

Tom van der Poll
1   The Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
2   Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
,
Sander J H van Deventer
1   The Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
2   Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
,
Gerard Pasterkamp
3   Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
,
Jan A van Mourik
3   Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
,
Harry R Büller
2   Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
,
Jan W ten Cate
2   Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 10 June 1991

Accepted after revision 15 January 1992

Publication Date:
03 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Tumor necrosis factor (TNF) is an important mediator of the host responses to systemic infection. To investigate the effect of TNF on the release of von Willebrand factor (vWF) into the circulation, we performed a controlled study in six healthy men, sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF (50 μg/m2). TNF induced a marked increase in vWF antigen plasma levels, becoming significant after 45 min and peaking after 4 h (percentage increase from base line: 351 ±46; p <0.0001, TNF versus saline). The multimeric organization of circulating vWF was not affected by TNF. We conclude that TNF may be an early mediator of increased vWF secretion in systemic infection.

 

  • References

  • 1 Foster PA, Zimmerman TS. Factor VIII structure and function. Blood Rev 1989; 3: 180-191
    CrossrefPubMedGoogle Scholar
  • 2 Pottinger BE, Read RC, Paleolog EM, Higgins PG, Pearson JD. Von Willebrand factor is an acute phase reactant in man. Thromb Res 1989; 53: 387-394
    CrossrefPubMedGoogle Scholar
  • 3 Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest 1990; 86: 474-480
    CrossrefPubMedGoogle Scholar
  • 4 Bendtzen K. Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity. Immunol Lett 1988; 19: 183-192
    CrossrefPubMedGoogle Scholar
  • 5 Hesse DG, Tracey KJ, Fong Y, Manogue KR, Palladino Jr MA, Cerami A, Shires GT, Lowry SF. Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 1988; 166: 147-153
    PubMedGoogle Scholar
  • 6 Michie HR, Manogue KR, Spriggs DR, Revhaug A, O’Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988; 318: 1481-1486
    CrossrefPubMedGoogle Scholar
  • 7 Van Deventer SJH, Biiller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 1990; 76: 2520-2526
    PubMedGoogle Scholar
  • 8 Fong Y, Tracey KJ, Moldawer LL, Hesse DG, Manogue KR, Kenney JS, Lee AT, Kuo GC, Allison AC, Lowry SF, Cerami A. Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 p and interleukin 6 appearance during lethal bacteremia. J Exp Med 1989; 170: 1627-1633
    CrossrefPubMedGoogle Scholar
  • 9 Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987; 330: 662-664
    CrossrefPubMedGoogle Scholar
  • 10 Harlan JM, Harker LA, Striker GE, Weaver LJ. Effects of lipopoly-saccharide on human endothelial cells in culture. Thromb Res 1983; 29: 15-26
    CrossrefPubMedGoogle Scholar
  • 11 Schorer AE, Moldow CF, Rick ME. Interleukin 1 or endotoxin increases the release of von Willebrand factor from human endothelial cells. Br J Haematol 1987; 67: 193-197
    CrossrefPubMedGoogle Scholar
  • 12 Booth F, Allington MJ, Cederholm-Williams SA. An in vitro model for the study of acute release of von Willebrand factor from human endothelial cells. Br J Haematol 1987; 67: 71-78
    CrossrefPubMedGoogle Scholar
  • 13 Giddings JC, Shall L. Enhanced release of von Willebrand factor by human endothelial cells in culture in the presence of phorbol myristate acetate and interleukin 1. Thromb Res 1987; 47: 259-267
    CrossrefPubMedGoogle Scholar
  • 14 Zavoico GB, Ewenstein BM, Schafer AI, Pober JS. IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis. J Immunol 1989; 142: 3993-3999
    PubMedGoogle Scholar
  • 15 Paleolog EM, Crossmann DC, McVey JH, Pearson JD. Differential regulation by cytokines of constitutive and stimulated secretion of von Willebrand factor from endothelial cells. Blood 1990; 75: 688-695
    CrossrefPubMedGoogle Scholar
  • 16 Tannenbaum SH, Gralnick HR. ³-Interferon modulates von Willebrand factor release by cultured human endothelial cells. Blood 1990; 75: 2177-2184
    PubMedGoogle Scholar
  • 17 Gralnick HR, McKeown LP, Wilson OM, Williams SB, Elin RJ. Von Willebrand factor release induced by endotoxin. J Lab Clin Med 1989; 113: 118-122
    PubMedGoogle Scholar
  • 18 Suffredini AF, Harpel PC, Parrillo JE. Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N Engl J Med 1989; 320: 1165-1172
    CrossrefPubMedGoogle Scholar
  • 19 Van der Poll T, Biiller HR, ten Cate H, Wortel CH, Bauer KA, van Deventer SJH, Hack CE, Sauerwein HP, Rosenberg RD, ten Cate JW. Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 1990; 322: 1622-1627
    CrossrefPubMedGoogle Scholar
  • 20 Van der Poll T, van Deventer SJH, Hack CE, Wolbink GJ, Aarden LA, Biiller HR, ten Cate JW. Effects on leukocytes following injection of tumor necrosis factor into healthy humans. Blood 1992; 79: 693-698
    PubMedGoogle Scholar
  • 21 Cejka J. Enzyme immunoassay for factor VUI-related antigen. Clin Chem 1982; 2: 1356-1358
    PubMedGoogle Scholar
  • 22 Ruggeri ZM, Zimmermann TS. The complex multimeric composition of factor VUI/von Willebrand factor. Blood 1981; 57: 1140-1143
    PubMedGoogle Scholar
  • 23 Sherry B, Cerami A. Cachectin/tumor necrosis factor exerts endocrine, paracrine and autocrine control of inflammatory responses. J Cell Biol 1988; 107: 1269-1277
    CrossrefPubMedGoogle Scholar
  • 24 Waage A, Halstensen A, Espevik T. Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1987; i: 355-357
    PubMedGoogle Scholar
  • 25 Girardin E, Grau GE, Dayer J-M, Roux-Lombard P. the J5 study group, Lambert P-H. Tumor necrosis factor and interleukin 1 in the serum of children with severe infectious purpura. N Engl J Med 1988; 319: 397-400
    CrossrefPubMedGoogle Scholar
  • 26 Bowie EJW, Solberg LA, Fass DN, Johnson CM, Knutson GJ, Stewart ML, Zoecklein LJ. Transplantation of normal bone marrow into a pig with severe von Willebrand’s disease. J Clin Invest 1986; 78: 26-30
    CrossrefPubMedGoogle Scholar
  • 27 Ribes JA, Francis CW, Wagner DD. Fibrin induces release of von Willebrand factor from endothelial cells. J Clin Invest 1987; 79: 117-123
    CrossrefPubMedGoogle Scholar
  • 28 de Groot PG, Gonsalves MD, Loesberg C, van Buul-Wortelboer MF, van Aken WG, van Mourik JA. Thrombin-induced release of von Willebrand factor from endothelial cells is mediated by phospholipid methylation. J Biol Chem 1984; 259: 13329-13333
    PubMedGoogle Scholar
  • 29 Ruggeri ZM, Mannucci PM, Lombardi R, Federici AB, Zimmerman TS. Multimeric composition of factor VUI/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand diseases subtypes. Blood 1982; 59: 1272-1278
    PubMedGoogle Scholar