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Thromb Haemost 1978; 40(01): 061-065
DOI: 10.1055/s-0038-1648634
Original Article
Schattauer GmbH Stuttgart

Effects of Autoprothrombin II-A on Epinephrine-Induced Platelet Aggregation of Normal- and Coumadin-Treated Dogs

Gilbert E Herman
The Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, U. S. A.
,
Walter H Seegers
The Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, U. S. A.
,
Raymond L Henry
The Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, U. S. A.
› Author Affiliations
Further Information

Publication History

Received 24 August 1977

Accepted 15 December 1977

Publication Date:
12 July 2018 (online)

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Summary

Platelet-rich plasma from dogs and from coumadin-treated dogs aggregated at the same optimum concentration of epinephrine. Neither protein C nor its active form called autoprothrombin II-A was necessary for aggregation of dog platelets with epinephrine. For platelet aggregation, suboptimal concentrations of epinephrine were potentiated by addition of purified autoprothrombin II-A. The latter, by itself, induced platelet aggregation in high concentration.

 

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