Download PDF
Thromb Haemost 1978; 40(01): 111-117
DOI: 10.1055/s-0038-1648640
Original Article
Schattauer GmbH Stuttgart

The Inhibiting Effect of a Plasma Globulin on Arterial Thrombus Formation (as Compared to Dipyridamole)

R H Bourgain
*   The Department of Physiology and Physiopathology, university of Brussels VUB, Belgium
,
F Six
*   The Department of Physiology and Physiopathology, university of Brussels VUB, Belgium
,
P Smets
**   The Department of scientific Computation, university of Brussels ULB, Belgium
› Author Affiliations
Further Information

Publication History

Received 06 December 1977

Accepted 28 January 1978

Publication Date:
12 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The inhibiting effect on arterial white thrombus formation of a globulin prepared from beef plasma has been compared to dipyridamole in white Wistar rats. It was demonstrated that the globulin fraction had a greater effect in inhibiting thrombus formation as judged by the lag time [t(1)], the maximal thrombus value [m(T)], the maximal thickness of the thrombus [m(D)] and the maximal thrombus surface [m(O)].

 

  • References

  • 1 Bourgain RH, Six F. 1974; A continuous registration method in experimental arterial thrombosis in the rat. Thrombosis Research 4: 599
    CrossrefPubMedSearch in Google Scholar
  • 2 Bourgain RH, Six F. 1975; The effect of defibrase on arterial thrombus formation. Thrombosis Research 6: 195
    CrossrefPubMedSearch in Google Scholar
  • 3 Bourgain RH, Potvliege P, Derwael E, Six F. 1975; La thrombose arterielle: interactions entre la paroi arterielle, les plaquettes et les proteines plasmatiques. Acta clinica Belgica 30: 159
    CrossrefPubMedSearch in Google Scholar
  • 4 Bourgain RH, Six F. 1977 Unpublished data
    PubMed
  • 5 Harker LA, Ross R, Glomset J. 1976; Role of the platelet in atherogenesis. Annals of The New York Academy of Sciences 275: 321
    CrossrefPubMedSearch in Google Scholar
  • 6 Potvliege PR, Bourgain RH. 1976; Thrombosis induced in vivo in the mesenteric artery of rats. An electron microscopic study of the initial phases The British Journal of Experimental Pathology 57: 722
    PubMedSearch in Google Scholar
  • 7 Potvliege PR, Bourgain RH. 1977 Thrombosis induced in vivo in the mesenteric artery of normal and thrombocytopenic rats. An electron microscopic study of the early arterial wall reaction. The British Journal of Experimental Pathology 58. accepted for publication
    PubMedSearch in Google Scholar
  • 8 Ross R, Glomset J. 1973; Atherosclerosis and the arterial smooth muscle cell. Science 180: 1332
    CrossrefPubMedSearch in Google Scholar
  • 9 Ross R, Glomset J, Kariya B, Harker L. 1974; A plateletdependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vivo. Proceedings of the National Academy of Sciences USA 71: 1207
    CrossrefPubMedSearch in Google Scholar
  • 10 Six F. 1976 Nieuwe methodologische aspecten voor de studie van de experimentele arteriële trombose. Thesis, V. U. B. (Free University of Brussels)
    PubMedSearch in Google Scholar