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Thromb Haemost 1978; 40(02): 532-541
DOI: 10.1055/s-0038-1648686
Original Article
Schattauer GmbH Stuttgart

Natural Oestrogen in the Female Climacteric - Influence on Blood Coagulation and Fibrinolysis

Anders Lagrelius
The Departments of Obstetrics and Gynecology, Huddinge Hospital, and Blood Coagulation Disorders, Karolinska Hospital, Stockholm, Sweden
,
Nils-Olov Lunell
The Departments of Obstetrics and Gynecology, Huddinge Hospital, and Blood Coagulation Disorders, Karolinska Hospital, Stockholm, Sweden
,
Margareta Blombäck
The Departments of Obstetrics and Gynecology, Huddinge Hospital, and Blood Coagulation Disorders, Karolinska Hospital, Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received 26 October 1977

Accepted 27 March 1978

Publication Date:
12 July 2018 (online)

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Summary

The aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.

The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

 

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