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Thromb Haemost 1994; 72(01): 039-043
DOI: 10.1055/s-0038-1648808
Original Article
Schattauer GmbH Stuttgart

Hypercoagulability and High Lipoprotein(a) Levels in Patients with Central Retinal Vein Occlusion

Francesco Bandello
1   The Department of Ophthalmology, University of Milano, Italy
,
Silvana Vigano’ D’Angelo
2   Coagulation Service, Scientific Institute IRCCS H S. Raffaele, Milano, Italy
,
Mariella Parlavecchia
3   Lipoprotein Laboratory, Scientific Institute IRCCS H S. Raffaele, Milano, Italy
,
Alessandra Tavola
1   The Department of Ophthalmology, University of Milano, Italy
,
Patrizia Della Valle
2   Coagulation Service, Scientific Institute IRCCS H S. Raffaele, Milano, Italy
,
Rosario Brancato
1   The Department of Ophthalmology, University of Milano, Italy
,
Armando D’Angelo
2   Coagulation Service, Scientific Institute IRCCS H S. Raffaele, Milano, Italy
› Author Affiliations
Further Information

Publication History

Received 08 September 1993

Accepted after resubmission 23 March 1994

Publication Date:
12 July 2018 (online)

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Summary

A series of coagulation parameters and lipoprotein(a) (Lp(a)) were explored in plasma from 40 patients with central retinal vein occlusion (CRVO, non-ischemic type n = 12; ischemic type n = 28) free of local and systemic predisposing factors, 1 to 12 months after the acute event. Forty age- and sex-matched patients with cataract served as controls. Prothrombin fragment 1.2 (FI.2), D-dimer, FVII:C - but not FVII: Ag - were higher and fibrinogen was lower in CRVO patients than in controls. Patients with non-ischemic CRVO had higher FI .2 and FVII:C and lower heparin cofactor II than patients with ischemic CRVO. Lp(a) levels greater than 300 mg/1 were observed in 12 patients with CRVO and in 4 controls (30% vs 10%, p <0.025). Patients with high Lp(a) - consistently associated with the S2 phenotype - had higher FVII:C, FVII:C/Ag ratio, and fibrinogen than the remaining CRVO patients. Plasma FI.2 and D-dimer correlated fairly in controls (r = 0.41) and patients with normal Lp(a) levels (r = 0.55), but they did not in the group of patients with high Lp(a) (r = 0.19), where the latter parameter was negatively related to D-dimer (r = −0.55). There was no dependence of the abnormalities observed on the time elapsed from vein occlusion. The findings of activated FVII and high FI.2, D-dimer, and Lp(a) are not uncommon in patients with CRVO. Increased thrombin formation with fibrin deposition and impaired fibrinolysis may play a role in the pathophysiology of CRVO and require specific treatment

 

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