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Thromb Haemost 1994; 72(01): 058-064
DOI: 10.1055/s-0038-1648811
Original Article
Schattauer GmbH Stuttgart

Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

Goya Wannamethee
The Department of Public Health and Primary Care, Royal Free Hospital School of Medicine, London, UK
,
A Gerald Shaper
The Department of Public Health and Primary Care, Royal Free Hospital School of Medicine, London, UK
› Author Affiliations
Further Information

Publication History

Received 15 December 1993

Accepted after revision 02 March 1994

Publication Date:
12 July 2018 (online)

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Summary

The relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.

Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

 

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