Studies on Blood Coagulation Factor V

H. C Hemker; M. J. P Kahn

doi:10.1055/s-0038-1649007

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 27(01): 033-042
DOI: 10.1055/s-0038-1649007

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Studies on Blood Coagulation Factor V

VI. The Inactivation of Factor V and Prothrombinase

H. C Hemker

¹Laboratory for Coagulation Biochemistry and Cardiovascular Biochemical Research, Clinic for Internal Medicine, University Hospital, Leiden, The Netherlands

,

M. J. P Kahn

¹Laboratory for Coagulation Biochemistry and Cardiovascular Biochemical Research, Clinic for Internal Medicine, University Hospital, Leiden, The Netherlands

› Author Affiliations

Abstract

Summary

The disappearance of factor V-activity from human plasma on storage can be described as a first order reaction with an activation energy of about 44 kcal/mol.

The disappearance of factor V- activity from bovine plasma in vitro is a second order reaction with an activation energy of about 66 kcal/mol.

The inactivation of human prothrombinase during coagulation is a second order reaction; the activation energy is about 10 kcal/mol. It is concluded that this inactivation involves a reaction of the factor V moiety of prothrombinase with free factor V.

Full Text

References

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