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Thromb Haemost 1972; 27(01): 059-062
DOI: 10.1055/s-0038-1649009
Originalarbeiten — Original Articles — Travaux Originaux
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Sedimentation Behavior of Fibrinogen from Normal and Bleeder Swine

R. G Cooper
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
,
C. N Cornell
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
,
M. E Muhrer
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
,
K Leimer
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
› Author AffiliationsThis investigation was supported by grant HE 07181 from the U. S. P. H. S. Exp. Sta. Paper =£7120.
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Publication Date:
29 June 2018 (online)

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Summary

The Missouri Bleeder Swine have prolonged bleeding time, low factor VIII levels, reduced platelet adhesion, and respond to plasma and serum transfusions in a manner similar to that of patients with von Willebrand’s disease. The swine disease is thus more similar to von Willebrand’s disease than to classical hemophilia. The present work demonstrates that the sedimentation behavior of fibrinogen from these bleeder swine is like that of normal swine and does not show the anomalous sedimentation pattern of fibrinogen from classical hemophiliacs.

 

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