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Thromb Haemost 1972; 28(03): 376-382
DOI: 10.1055/s-0038-1649021
Original Article
Schattauer GmbH

Plasma Fibrinolytic Activity Associated with Flurothyl Induced Convulsion

Richard G. Cooper
1   Departments of Agricultural Chemistry, Pharmacology, and Physiology, University of Missouri, Columbia, Mo.
,
O. Lynn Webb
1   Departments of Agricultural Chemistry, Pharmacology, and Physiology, University of Missouri, Columbia, Mo.
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

Blood drawn from rats following convulsion produced by inhalation of flurothyl appeared to be hypocoagulable. Prothrombin times and partial thromboplastin times on plasma tested soon after convulsion were significantly prolonged, but euglobulin lysis times were greatly shortened (controls mean = 174 minutes, convulsed mean = 35 minutes, P <0.005). Several additional experiments were performed in an attempt to determine what component of the convulsive experience was responsible for the increased fibrinolysis. Flurothyl vapors passed through citrated rat blood in vitro did not alter the euglobulin lysis time. Rats paralyzed with gallamine triethiodide and supported by artificial ventilation were subjected to flurothyl vapors and the convulsion monitored by electroencephalography. Post-convulsion plasma from these animals had euglobulin lysis times that did not differ significantly from suitable controls. Rats convulsed in convulsion chambers with increased ambient oxygen percentage had shortened euglobulin lysis times similar to those convulsed in chambers containing room air. We believe these data eliminate both direct action of the drug on blood and a direct action through the central nervous system. The enhanced fibrinolytic activity may be secondary to the muscular activity or asphyxia associated with the convulsion.

 

  • References

  • 1 Astrup T, Rasmussen J, Amery A, and Poulsen H. F. 1960; Fibrinolytic activity of cirrhotic liver. Nature 185: 619.
    CrossrefPubMedSearch in Google Scholar
  • 2 Biggs R, MacFarlane R. G, and Pilling T. 1947; Observations on fibrinolysis. Experimental activity produced by exercise or adrenaline. Lancet 1: 402.
    PubMedSearch in Google Scholar
  • 3 Fantl P, and Simon S. E. 1958; Fibrinolysis following electrically induced convulsions. Australian Journal of Experimental Biology and Medical Science 26: 521.
    PubMedSearch in Google Scholar
  • 4 Kowaezyk H, Baciu I, Oppvisia C, and Kotschy M. 1962; Studies on the activation of fibrinolysis. Archivum immunologiae et therapiae experimentalis 10: 479.
    PubMedSearch in Google Scholar
  • 5 Kwaan H. C, Lo R, and McFadzean A. J. S. 1957; On the production of plasma fibrinolytic activity within veins. Clinical Science 16: 241.
    PubMedSearch in Google Scholar
  • 6 Kwaan H. C, Lo R, and McFadzean A. J. S. 1957; The production of plasma fibrinolytic activity in vivo by serotonin (5-hydroxytryptamine) creatinine sulphate. Clinical Science 16: 255.
    PubMedSearch in Google Scholar
  • 7 Kwaan H. C, Lo R, and McFadzean A. J. S. 1958; On the lysis of thrombi experimentally produced within veins. British Journal of Haematology 4: 51.
    CrossrefPubMedSearch in Google Scholar
  • 8 Latnepv A. L. 1947; Anxiety as a cause of fibrinolysis. Lancet 1: 194.
    PubMedSearch in Google Scholar
  • 9 MacFapvlane R. G, and Biggs R. 1946; Observations on fibrinolysis. Spontaneous activity associated with surgical operation, trauma, etc. Lancet 2: 862.
    CrossrefPubMedSearch in Google Scholar
  • 10 Mole R. H. 1948; Fibrinolysin and the fluidity of the blood postmortem. Journal of Pathology and Bacteriology 60: 413.
    CrossrefPubMedSearch in Google Scholar
  • 11 Mullertz S. 1952; Fibrinolytic activity of human blood after death. Acta. Physiologica Scandinavica 27: 265.
    PubMedSearch in Google Scholar
  • 12 Mullertz S. 1953; A plasminogen activator in spontaneously active human blood. Proceedings of the Society for Experimental Biology and Medicine 82: 291.
    PubMedSearch in Google Scholar
  • 13 Sherry S, Lindemeyer R. I, Fletcher A. P, and Alkjaersig N. 1959; Studies on enhanced fibrinolytic activity in man. Journal of Clinical Investigation 38: 810.
    CrossrefPubMedSearch in Google Scholar
  • 14 Thigpen C. H. (Chairman) 1963; Symposium on Indoklon. Journal of Neuropsychiatry 4: 152.
    PubMedSearch in Google Scholar
  • 15 Truelove S. C. 1953; The lability of human fibrinolysin. Clinical Science 12: 75.
    PubMedSearch in Google Scholar
  • 16 Truitt Jr. E. B., Ebersberger E. M, and Ling A. S. C. 1960; Measurement of brain excitability by the use of hexafluorodiethyl ether (Indoklon). Journal of Pharmacology 129: 445.
    PubMedSearch in Google Scholar
  • 17 Tyminski W, Czestochowska E, Szlobowicz J. 1970; Relationship between electrical shock and fibrinolysis. Thrombosis et Diathesis Haemorrhagica 24: 507.
    PubMedSearch in Google Scholar
  • 18 Ware A. G, Guest M. M, and Seegers W. H. 1947; Fibrinogen: with special reference to its preparation and certain properties of the product. Archives of Biochemistry and Biophysics 13: 231.
    PubMedSearch in Google Scholar
  • 19 Webb O. L. 1966 The flurothyl convulsion. Dissertation, University of Missouri, Supervisor R. L. Russell.
    PubMedSearch in Google Scholar