The Effect of Venous Occlusion on the Sequestration of Blood Platelets

J Hladovec; Z Koleilat; I Přerovský

doi:10.1055/s-0038-1649022

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(03): 383-392
DOI: 10.1055/s-0038-1649022

Original Article

Schattauer GmbH

The Effect of Venous Occlusion on the Sequestration of Blood Platelets

J Hladovec

¹Research Centre of Cardiovascular Diseases (Head: L. Hejhal, M. D., DrSc), Institute of Clinical and Experimental Medicine (Director: P. Malek, M. D., DrSc.), Prague 4 - Krč.

,

Z Koleilat^*

,

I Přerovský

¹Research Centre of Cardiovascular Diseases (Head: L. Hejhal, M. D., DrSc), Institute of Clinical and Experimental Medicine (Director: P. Malek, M. D., DrSc.), Prague 4 - Krč.

› Author Affiliations

Abstract

Summary

The venous occlusion of all four legs in rats caused a highly significant decrease of platelet counts in venous blood especially after the correction for an opposite change in haematocrit. A very pronounced decrease in platelets was observed in human volunteers after a venostasis in one arm in the blood drawn from the occluded limb just before the release of occlusion. Similar decreases were found after a venostasis of both legs in postocclusion blood samples. The decrease in blood platelets results from temporary sequestration in the occluded limbs. The decreases of platelets after a 10 min occlusion of both legs are more pronounced in patients with post thrombotic states.

Full Text

References

References
1 Clarke R. L, Orandi E. E, and Cliffton E. E. 1960; Induction of fibrinolysis by venous obstruction. Angiology 11: 367.
2 Hladovec J. 1969 Citrate and the mechanism of inflammation. In: Bertelli A, and Houck J. C. (eds.) Inflammation Biochemistry and Drug Interaction. Proceedings of an International Symposium, Gomo. 1968, p. 228.
3 Hladovec J, Svobodová J, and Rossmann P. 1970; a Influence of citrate on platelet adhesion to the endothelial surface. Physiologia bohemoslovaca 19: 421.
4 Hladovec J. 1970; b Cement substance and platelet adhesion to the endothelial surface. Influence of several groups of drugs. Physiologia bohemoslovaca 19: 425.
5 Hladovec J. (in print): Factors modifying the interaction of platelets with the vessel wall. In: Symposium on the Role of Platelets in Haemostasis and Thrombosis. Prague: 1971
6 Holzknecht F, Spöttl F, Constantini R, Knapp E, Herbst M, and Braunsteiner H. 1970; Platelet adhesion before and after venous occlusion. Atherosclerosis 11: 105.
7 Jervell O. 1928 Investigation of the concentration of lactic acid in blood and urine. Acta Medica Scandinavica, Suppl. No. 24.
8 Maino G. 1970 Two endothelial “novelties”: Endothelial contraction; collagenase digestion of the basement membrane. In: Koller F, Brinkhous K. M, Biggs R, Rodman N. F, and Hinnom S. (eds.) Vascular Factors and Thrombosis, Transactions of the Conference, Bath. October 1969, p. 23.
9 Piette M, and Piette C. 1959; Numération de plaquettes sanguines utilisant un liquid hypotonique à base de chlorhydrate de procaine. Sang 30: 144.
10 Sarajas J. S. S, and Myllylä G. 1965; Stasis-induced changes in platelet adhesiveness. Experientia (Basel) 21: 223.
11 Tranzer J. P, and Baumgartner H. R. 1967; Filling gaps in the vascular endothelium with blood platelets. Nature (London) 216: 1126.