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Thromb Haemost 1972; 28(03): 383-392
DOI: 10.1055/s-0038-1649022
Original Article
Schattauer GmbH

The Effect of Venous Occlusion on the Sequestration of Blood Platelets

J Hladovec
1   Research Centre of Cardiovascular Diseases (Head: L. Hejhal, M. D., DrSc), Institute of Clinical and Experimental Medicine (Director: P. Malek, M. D., DrSc.), Prague 4 - Krč.
,
Z Koleilat   *
,
I Přerovský
1   Research Centre of Cardiovascular Diseases (Head: L. Hejhal, M. D., DrSc), Institute of Clinical and Experimental Medicine (Director: P. Malek, M. D., DrSc.), Prague 4 - Krč.
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

The venous occlusion of all four legs in rats caused a highly significant decrease of platelet counts in venous blood especially after the correction for an opposite change in haematocrit. A very pronounced decrease in platelets was observed in human volunteers after a venostasis in one arm in the blood drawn from the occluded limb just before the release of occlusion. Similar decreases were found after a venostasis of both legs in postocclusion blood samples. The decrease in blood platelets results from temporary sequestration in the occluded limbs. The decreases of platelets after a 10 min occlusion of both legs are more pronounced in patients with post thrombotic states.

* Research fellow of the Lebanese Research Council.


 

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