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Thromb Haemost 1972; 28(01): 049-053
DOI: 10.1055/s-0038-1649040
Original Article
Schattauer GmbH

Kymographic Recording of Clot Retraction: Effects of Papaverine. Theophylline and Cytochalasin B

G Majno
1   Department of Pathology and Hematology Division, Geneva University Hospital, Geneva, Switzerland
,
C.A Bouvier
1   Department of Pathology and Hematology Division, Geneva University Hospital, Geneva, Switzerland
,
G Gabbiani
1   Department of Pathology and Hematology Division, Geneva University Hospital, Geneva, Switzerland
,
G.B Ryan
1   Department of Pathology and Hematology Division, Geneva University Hospital, Geneva, Switzerland
,
P Statkov
1   Department of Pathology and Hematology Division, Geneva University Hospital, Geneva, Switzerland
› Author Affiliations
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

Clot retraction was studied by setting up ribbon-shaped clots in a pharmacological bath and recording the progress of contraction on a kymograph. Drugs could be added to the bath or washed out at any stage. Papaverine, theophylline and cytochalasin B each reversed the upward course of the kymograph tracing ; contraction began again when the drugs were washed from the bath. This phenomenon resembles the behaviour of smooth muscle under similar circumstances.

 

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