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Thromb Haemost 1972; 28(02): 182-193
DOI: 10.1055/s-0038-1649054
Original Article
Schattauer GmbH

Cold Promoted Activation of Factor VII

III. Relation to the Kallikrein System
H Gjønniess
1   Institute for Thrombosis Research, University of Oslo, Rikshospitalet, (Chief: H. Stormorken) Oslo, Norway
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

Several known activators of the plasma kallikrein system were tested for the ability to induce cold promoted activation of factor VII.

All the prekallikrein activators tested (EACA, trypsin, acetone, urokinase, kaolin, Liquoid, ellagic acid) revealed generation of factor VII activator activity (CPA). Simultaneously the plasma kallikrein system was activated. A good correlation was demonstrated between the factor VII activation and the kallikrein activity.

Glandular kallikrein, bradykinin, or kallidin revealed no effect on the coagulation system. Thus, the correlation between the factor VII activation and the kallikrein system seemed to be restricted to plasma kallikrein.

 

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