Parallel Determinations of FDP and Fibrin Monomers with Various Methods

Summary

The following tests were performed in 305 persons with one or other of the following conditions: malignant disease, postoperative complications, sepsis or multiple fractures, liver disease, pregnancy, the puerperium, renal disease, dysproteinaemia and different blood disorders : 1. fibrinogen degradation products (FDP) with Niléhn’s immunochemical method; 2. the thrombin time; 3. the Reptilase time; 4. the ethanol gelation test; 5. the protamine sulphate precipitation test. It was found that a prolonged thrombin time or Reptilase time in a given case was not necessarily a sign of the presence of FDP. Thus, neither determination of the thrombin time nor of the Reptilase time can substitute for specific determination of FDP. A positive ethanol gelation test was found in only 5 out of 17 patients with a low platelet count, low P & P test, low factor V, low fibrinogen and clinical signs of disseminated intravascular coagulation such as shock, disturbance of the periphery circulation, oliguria or anuria. No association was found between a positive ethanol gelation test and the presence of FDP. The protamine sulphate precipitation test was positive in only one of the 305 patients.

• References

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