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Thromb Haemost 1973; 30(02): 280-283
DOI: 10.1055/s-0038-1649075
Original Article
Schattauer GmbH

On the Complex Formation of Antithrombin III with Thrombin

Gelfiltration Studies on Human Plasma and Serum
B Binder
1   Department of Physiology (Director Prof. Dr. W. Auerswald), School of Medicine, University of Vienna
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Publikationsverlauf

Received for publication 23. November 1972

Accepted for publication 12. Juni 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

Based on gelfiltration studies, the part of AT III which becomes bound to thrombin during the process of in vitro blood coagulation was calculated to be about 40% of total AT III. Complexes consisting of one AT III and one thrombin molecule could not be detected while fractions corresponding to molecular weights of about 190,000 Dalton show AT III as well as thrombin activities. The AT III - thrombin complex in normal human serum consists, therefore, of either 2 AT III and 2 thrombin molecules or of one AT III and 4 thrombin molecules.

 

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