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Thromb Haemost 1973; 30(02): 347-351
DOI: 10.1055/s-0038-1649084
Original Article
Schattauer GmbH

Generalized Shwartzman Reaction Induced by Liquoid in the Rat

Increased DNA-Synthesis in Aortic Endothelium
Stein A. Evensen   *
1   Biological Science Center, Boston University, Boston, Mass. 02215, USA
,
David Shepro
1   Biological Science Center, Boston University, Boston, Mass. 02215, USA
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Publikationsverlauf

Received for publication 22. März 1973

Accepted for publication 15. Juni 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

In an autoradiographic study the number of DNA-synthesizing aortic endothelial cells was compared 48 hours after an intravenous injection of the acidic polymer Liquoid or saline in rats. Doses of 1.5-2 mg per 100 g body weight produced a 14-fold increase in DNA-synthesizing endothelial cells and the generalized Shwartzman reaction. These results show that Liquoid causes severe endothelial injury.

* Present adress: Medical Department A, Rikshospitalet, Oslo 1, Norway


 

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