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Thromb Haemost 1973; 30(02): 381-392
DOI: 10.1055/s-0038-1649088
Original Article
Schattauer GmbH

Studies on Activator Formation in Human Plasma with Streptokinase

I. Experimental Studies
M Martin
1   Medizinische Universitäts-Poliklinik Bonn and the Aggertalklinik Engelskirchen bei Köln
,
with the technical assistance of Frau R. Albrecht and Frau M. Altmaier › Author Affiliations
Further Information

Publication History

Received for publication 08 December 1972

Accepted for publication 16 May 1973

Publication Date:
24 July 2018 (online)

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Summary

The plasminogen-streptokinase complex called “activator” was present in diluted plasma in the form of a largely dissociated mixture. More than ⅞ of the streptokinase and plasminogen molecules were available for further activator formation.

The activator is probably a dissociated complex of the formula

Streptokinase + Plasminogen ⇄ Activator.

The fact that an increase in activator concentration by x times is obtained by multiplying either the streptokinase content by the factor y or the plasminogen concentration by the same factor y would point to a kinetic effect along the lines of the mass action law.

 

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