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Thromb Haemost 1973; 30(02): 403-413
DOI: 10.1055/s-0038-1649090
Original Article
Schattauer GmbH

Preferential Degradation of Soluble Fibrin Monomers in Streptokinase-activated Plasma

Y. P Konttinen
1   Medical and Laboratory Departments of Maria Hospital, Helsinki, Finland
,
M.L.T Lalla
1   Medical and Laboratory Departments of Maria Hospital, Helsinki, Finland
,
O Turunen
1   Medical and Laboratory Departments of Maria Hospital, Helsinki, Finland
› Author Affiliations
Further Information

Publication History

Received for publication 04 April 1973

Accepted for publication 18 June 1973

Publication Date:
30 June 2018 (online)

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Summary

Degradation of 125I-labelled fibrin monomers and 125I-fibrinogen in streptokinase-activated plasma was investigated. Release of the label proceeded at a much higher rate from soluble fibrin monomer complexes than from fibrinogen until ca. 70% of the label was recovered in the serum. It is concluded that the fibrinolytic system has an essentially higher affinity to monomers than to fibrinogen, but that the specificity of the monomers as substrate may be limited to the early steps of degradation. It is suggested that the preferential splitting of fibrin monomer complexes may be important in the body’s defence against pathological fibrin formations derived from paracoagulable fibrin.

 

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