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Thromb Haemost 1973; 30(01): 012-017
DOI: 10.1055/s-0038-1649097
Original Article
Schattauer GmbH

A Controlled Trial of Aspirin in Childhood Glomerular Disorders

Carl W. Trygstad   *
1   Department of Pediatrics and Medicine, Indiana University-Purdue University Indianapolis, School of Medicine and Lilly Laboratory for Clinical Research
,
Nils U. Bang
1   Department of Pediatrics and Medicine, Indiana University-Purdue University Indianapolis, School of Medicine and Lilly Laboratory for Clinical Research
,
Robert O. Heldenreich
1   Department of Pediatrics and Medicine, Indiana University-Purdue University Indianapolis, School of Medicine and Lilly Laboratory for Clinical Research
,
Barbara M. Csiscko
1   Department of Pediatrics and Medicine, Indiana University-Purdue University Indianapolis, School of Medicine and Lilly Laboratory for Clinical Research
,
Bruce Rodda
1   Department of Pediatrics and Medicine, Indiana University-Purdue University Indianapolis, School of Medicine and Lilly Laboratory for Clinical Research
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Publikationsverlauf

Received for publication 12. Juni 1973

Accepted for publication 06. Juli 1973

Publikationsdatum:
24. Juli 2018 (online)

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Summary

A controlled, prospective, double-blind study of the effect of aspirin on the clinical course and renal function of 36 children with proliferative glomerulonephritis or the nephrotic syndrome was undertaken. Despite unequivocal evidence of suppression of platelet aggregation with aspirin treatment, there were no statistically significant changes in the clinical course or any of the laboratory parameters denoting activity of the chronic glomerular renal disorder. It would appear, therefore, that additional factors besides local platelet aggregation must be involved in the perpetuation of chronic childhood renal disease.

* Reprint address: CWT, Department of Pediatrics, Harbor General Hospital, UCLA School of Medicine, 1000 West Carson Street, Torrance, California 90509.


 

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