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Thromb Haemost 1973; 30(01): 018-024
DOI: 10.1055/s-0038-1649098
Original Article
Schattauer GmbH

Trial of Aspirin and RA 233 in Prevention of Post-operative Deep Vein Thrombosis

Edward H. Wood
1   University Department of Medicine and Division of Surgery, Royal Infirmary, Glasgow, Scotland
,
Colin R.M. Prentice
1   University Department of Medicine and Division of Surgery, Royal Infirmary, Glasgow, Scotland
,
D. Angus McGrouther
1   University Department of Medicine and Division of Surgery, Royal Infirmary, Glasgow, Scotland
,
John Sinclair
1   University Department of Medicine and Division of Surgery, Royal Infirmary, Glasgow, Scotland
,
George P. McNicol   *
1   University Department of Medicine and Division of Surgery, Royal Infirmary, Glasgow, Scotland
› Institutsangaben
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Publikationsverlauf

Received for publication 08. Mai 1973

Accepted for publication 17. Juni 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

Although the oral anticoagulants provide effective prophylaxis against postoperative deep vein thrombosis following fracture of neck of femur there is a need for an antithrombotic agent which needs less laboratory control and does not cause haemorrhagic complications. It has been suggested that drugs causing inhibition of platelet function may fulfil these requirements. A controlled trial was carried out in which aspirin, RA 233, or a combination of these drugs was compared with a placebo in the prevention of post-operative deep vein thrombosis. In thirty patients undergoing surgery for fractured neck of femur the incidence of post-operative calf vein thrombosis, as detected by 125I-fibrinogen scanning, was not significantly different between the untreated and treated groups.

* Present address : Department of Medicine, The General Infirmary, Leeds.


 

  • References

  • 1 Atkins P, and Hawkins L. A. 1968; The Diagnosis of Deep-Vein Thrombosis in the Leg Using 125I-Fibrinogen. British Journal of Surgery 55: 825.
    CrossrefPubMedSuche in Google Scholar
  • 2 Bennet P. N, Dhall D. P, and Matheson N. A. 1968; Effect of Dextran 70 Infusion on Platelet Adhesiveness after Operation. British Journal of Surgery 55: 289.
    CrossrefPubMedSuche in Google Scholar
  • 3 Bonnae J, and Walsh J. 1972; Prevention of Thrombosis after Pelvic Surgery by British Dextran 70. Lancet 1: 614.
    PubMedSuche in Google Scholar
  • 4 Breddin K, and Sharker I. 1972 Clinical Experience with Acetylsalicylic Acid as an Anti-Thrombotic Agent. Abstract, III Congress International Society on Thrombosis and Haemostasis, Washington, p. 414.
    PubMedSuche in Google Scholar
  • 5 Browse N. L, and Hall J. H. 1969; Effect of Dipyridamole on the Incidence of Clinically Detectable Deep-Vein Thrombosis. Lancet 2: 718.
    PubMedSuche in Google Scholar
  • 6 Browse N. L, and Negus D. 1970; Prevention of Post-operative Leg Vein Thrombosis by Electrical Muscle Stimulation. An Evaluation with 125I-labelled Fibrinogen. British Medical Journal 3: 615.
    CrossrefPubMedSuche in Google Scholar
  • 7 Calnan J. S, Pflug J.J, and Mills C. J. 1970; Pneumatic Intermittent Compression Legging Simulating Calf Muscle Pump. Lancet 2: 502.
    PubMedSuche in Google Scholar
  • 8 Doran F. S. A, Drury M, and Sivyer A. 1964; A Simple Way to Combat the Venous Stasis which Occurs in the Lower Limbs during Surgical Operations. British Journal of Surgery 51: 486.
    CrossrefPubMedSuche in Google Scholar
  • 9 Doran F. S. A, and White H. M. 1967; A Demonstration that the Risk of Post-operative Deep Venous Thrombosis is Reduced by Stimulating the Calf Muscles Electrically During the Operation. British Journal of Surgery 54: 686.
    CrossrefPubMedSuche in Google Scholar
  • 10 Flanc C, Kakkar V. V, and Clark M. B. 1968; The Detection of Venous Thrombosis of the Legs Using 125I-labelled Fibrinogen. British Journal of Surgery 55: 742.
    CrossrefPubMedSuche in Google Scholar
  • 11 Harris W. H, Salzman E. W, and De Sanctis R. W. 1967; The Prevention of Thromboembolic Disease by Prophylactic Anticoagulation. Journal of Bone and Joint Surgery 49A: 81.
    PubMedSuche in Google Scholar
  • 12 Hassanein A. A, Turpie A. G. G, McNicol G. P, and Douglas A. S. 1970; Effect of RA 233 on Platelet Function in Vitro. British Medical Journal 2: 83.
    CrossrefPubMedSuche in Google Scholar
  • 13 Hills N.H, Pflug J. J, Jeyasingh K, Boardman L, and Calnan J. S. 1972; Prevention of Deep Vein Thrombosis by Intermittent Pneumatic Compression of Calf. British Medical Journal 1: 131.
    CrossrefPubMedSuche in Google Scholar
  • 14 Kakkar V. V, Corrigan T, Spindler J, Fossard D. P, Flute P. T, Crellin R. Q, Wessler S, and Yin E. T. 1972; Efficacy of Low Doses of Heparin in Prevention of Deep-Vein Thrombosis after Major Surgery. Lancet 2: 101.
    PubMedSuche in Google Scholar
  • 15 Kakkar V. V, Field E. S, Nicolaides A. N, Flute P. T, Wessler S, and Yin E. T. 1971; Low Doses of Heparin in Prevention of Deep Vein Thrombosis. Lancet 2: 669.
    PubMedSuche in Google Scholar
  • 16 Lambie J.M, Barber D. C, Dhall D. P, and Matheson N. A. 1970; Dextran 70 in Prophylaxis of Post-operative Venous Thrombosis. A Controlled Trial. British Medical Journal 2: 144.
    CrossrefPubMedSuche in Google Scholar
  • 17 Lindsay R. M, Prentice C. R. M, Ferguson D, Burton J. A, and McNicol G. P. 1972; Reduction of Thrombus Formation on Dialyser Membranes by Aspirin and RA 233. Lancet 2: 1287.
    PubMedSuche in Google Scholar
  • 18 Negus D, Pinto D. J, Le Quesne L. P, Brown N, and Chapman M. 1968; 125I-labelled Fibrinogen in the Diagnosis of Deep-Vein Thrombosis and its Correlation with Phlebography. British Journal of Surgery 55: 835.
    CrossrefPubMedSuche in Google Scholar
  • 19 O’Brien J. R. 1968; Effects of Salicylates on Human Platelets. Lancet 1: 779.
    PubMedSuche in Google Scholar
  • 20 O’Sullivan E. F, and Renney J. T. G. 1972 Anti-platelet Drugs in the Prevention of Postoperative Deep-Vein Thrombosis. Abstract, III Congress International Society on Thrombosis and Haemostasis, Washington, p. 438.
    PubMedSuche in Google Scholar
  • 21 Report of Steering Committee. 1972; Effect of Aspirin on Post-operative Venous Thrombosis. Lancet 2: 441.
    PubMedSuche in Google Scholar
  • 22 Sabri S, Roberts V. C, and Cotton L. T. 1971; Prevention of Early Post-operative Deep Vein Thrombosis, by Passive Exercise of Leg During Surgery. British Medical Journal 3: 82.
    CrossrefPubMedSuche in Google Scholar
  • 23 Salzman E. W, Harris W. H, and De Sanctis R. W. 1966; Anticoagulation for Prevention of Thromboembolism Following Fractures of the Hip. New England Journal of Medicine 275: 122.
    CrossrefPubMedSuche in Google Scholar
  • 24 Salzman E. W, Harris W. H, and De Sanctis R. W. 1971; Reduction in Venous Thromboembolism by Agents Affecting Platelet Function. New England Journal of Medicine 284: 1287.
    CrossrefPubMedSuche in Google Scholar
  • 25 Sevitt S. 1968; Thrombo-embolism and its Prevention. Proceedings of the Royal Society of Medicine 61: 143.
    PubMedSuche in Google Scholar
  • 26 Sevitt S, and Gallagher N. G. 1959; Prevention of Venous Thrombosis and Pulmonary Embolism in Injured Patients. Lancet 2: 981.
    PubMedSuche in Google Scholar
  • 27 Stuart R. K. 1970; Platelet Function Studies in Human Beings Receiving 300 mg. of Aspirin per day. Journal of Laboratory and Clinical Medicine 75: 463.
    PubMedSuche in Google Scholar
  • 28 Weiss H. J, and Aledort L. M. 1967; Impaired Platelet Connective Tissue Reaction in Man after Aspirin Ingestion. Lancet 2: 495.
    PubMedSuche in Google Scholar
  • 29 Williams H. T. 1971; Prevention of Post-operative Deep-Vein Thrombosis with Peri-operative Subcutaneous Heparin. Lancet 2: 950.
    PubMedSuche in Google Scholar
  • 30 Wood E. H, Prentice C. R. M, and McNicol G. P. 1972; Association of Fibrinogen fibrin-related Antigen (F. R.-antigen) with Post-operative Deep-vein Thrombosis and Systemic Complications. Lancet 1: 166.
    PubMedSuche in Google Scholar
  • 31 Zucker M. B, and Peterson J. 1968; Inhibition of Adenosine Diphosphate-induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion. Proceedings of the Society of Experimental and Biological Medicine 127: 547.
    PubMedSuche in Google Scholar