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Thromb Haemost 1973; 30(01): 114-122
DOI: 10.1055/s-0038-1649107
Original Article
Schattauer GmbH

Evaluation of a New Preparation of Urokinase

C.R.M Prentice
1   University Department of Medicine, Royal Infirmary, Glasgow G4 OSF, Scotland
,
K.M Rogers
1   University Department of Medicine, Royal Infirmary, Glasgow G4 OSF, Scotland
,
G.P McNicol   *
1   University Department of Medicine, Royal Infirmary, Glasgow G4 OSF, Scotland
› Author Affiliations
Further Information

Publication History

Received for publication 03 January 1973

Accepted for publication 22 June 1973

Publication Date:
30 June 2018 (online)

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Summary

The pharmacological effect of a new preparation of urokinase (Leo) has been studied, both in vitro and in six patients suffering from thrombo-embolic disorders. It was a non-toxic, effective fibrinolytic agent if given in sufficient dosage. A regimen consisting of an initial dose of 7,200 ploug units per kg body weight, followed by hourly maintenance therapy with 3,600 ploug units per kg intravenously, gave satisfactory evidence of whole body fibrinolytic activity. The preparation had minor but insignificant thromboplastic activity both when assayed in the laboratory and when given to patients.

* Present position: Professor of Medicine, The General Infirmary, Leeds.


 

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