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Thromb Haemost 1973; 30(01): 155-159
DOI: 10.1055/s-0038-1649112
Original Article
Schattauer GmbH

Platelet Factor 3 Activity Made Available from Human Platelets by ADP

Inhibition by Colchicine
Michael Gold   *
1   Biological Science Center, Boston University, Boston, Massachusetts 02215, USA
,
Stein A. Evensen   **
1   Biological Science Center, Boston University, Boston, Massachusetts 02215, USA
,
F.A Belamarich
1   Biological Science Center, Boston University, Boston, Massachusetts 02215, USA
,
David Shepro
1   Biological Science Center, Boston University, Boston, Massachusetts 02215, USA
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Publikationsverlauf

Received for publication 09. April 1973

Accepted for publication 23. Juli 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

Pretreament of normal human platelets with colchicine at a final concentration of 10-3 M strikingly modifies their subsequent reaction to ADP. The generation of platelet factor 3 activity is inhibited, the secondary wave of aggregation fails to appear, and platelet factor 4 is not released. Colchicine also inhibits the increase in platelet factor 3 activity that results from washing and centrifugation of platelets.

* Present address : Albert Einstein School of Medicine, Bronx, New York.


** Present address : Medical Department A, Rikshospitalet, Oslo, Norway.


 

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