Platelet Factor 3 Activity Made Available from Human Platelets by ADP

Michael Gold; Stein A. Evensen; F.A Belamarich; David Shepro

doi:10.1055/s-0038-1649112

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1973; 30(01): 155-159
DOI: 10.1055/s-0038-1649112

Original Article

Schattauer GmbH

Platelet Factor 3 Activity Made Available from Human Platelets by ADP

Inhibition by Colchicine

Michael Gold^*

¹Biological Science Center, Boston University, Boston, Massachusetts 02215, USA

,

Stein A. Evensen^**

¹Biological Science Center, Boston University, Boston, Massachusetts 02215, USA

,

F.A Belamarich

¹Biological Science Center, Boston University, Boston, Massachusetts 02215, USA

,

David Shepro

¹Biological Science Center, Boston University, Boston, Massachusetts 02215, USA

› Institutsangaben

Abstract

Summary

Pretreament of normal human platelets with colchicine at a final concentration of 10^-3 M strikingly modifies their subsequent reaction to ADP. The generation of platelet factor 3 activity is inhibited, the secondary wave of aggregation fails to appear, and platelet factor 4 is not released. Colchicine also inhibits the increase in platelet factor 3 activity that results from washing and centrifugation of platelets.

Volltext

Referenzen

References
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