Further Evidence for a Humoral Control of Factor VIII Plasma Levels

Ricardo H. Landaburu; Delicia E. Castellanos

doi:10.1055/s-0038-1649124

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(03): 460-470
DOI: 10.1055/s-0038-1649124

Original Article

Schattauer GmbH

Further Evidence for a Humoral Control of Factor VIII Plasma Levels

Ricardo H. Landaburu

¹Laboratorio de Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina

,

Delicia E. Castellanos

¹Laboratorio de Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina

› Author Affiliations

Abstract

Summary

Factor VIII increase after stress or adrenergic stimulation appears to be justified by ACTH release, which in turn liberates a principle other than steroids, from the adrenal cortex. A substance isolated from adrenal cortex and denominated S3 increase, when injected, the level of plasma factor VIII. The rise in factor VIII after S3 also occurs in adrenalectomized animals where ACTH or catecholamines administration gives negative results.

Full Text

References

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