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Thromb Haemost 1973; 30(03): 494-498
DOI: 10.1055/s-0038-1649127
Original Article
Schattauer GmbH

Effect of Aspirin on the Thrombelastogram of Human Blood

G de Gaetano   *
1   Laboratory of Blood Coagulation, Medical Research Department, Academisch Ziekenhuis St. Rafael, University of Leuven, Belgium
,
J Vermylen
1   Laboratory of Blood Coagulation, Medical Research Department, Academisch Ziekenhuis St. Rafael, University of Leuven, Belgium
› Author Affiliations
Further Information

Publication History

Received 04 July 1973

Accepted 14 August 1973

Publication Date:
30 June 2018 (online)

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Summary

Thrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

* Present address: Laboratory for Haemostasis and Thrombosis Research, Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, 20157 Milano, Italy.


 

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