Effects of Puff Adder Venom on the Coagulation Mechanism

Louise L. Phillips; H. J Weiss; N. P Christy

doi:10.1055/s-0038-1649128

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(03): 499-508
DOI: 10.1055/s-0038-1649128

Original Article

Schattauer GmbH

Effects of Puff Adder Venom on the Coagulation Mechanism

II. In Vitro

Louise L. Phillips

¹Department of Medicine, The Roosevelt Hospital and College of Physicians and Surgeons, Columbia University New York, N.Y.

,

H. J Weiss

¹Department of Medicine, The Roosevelt Hospital and College of Physicians and Surgeons, Columbia University New York, N.Y.

,

N. P Christy

¹Department of Medicine, The Roosevelt Hospital and College of Physicians and Surgeons, Columbia University New York, N.Y.

› Author Affiliations

Abstract

Summary

Studies of the in vitro effects of puff adder venom (Bitis arietans) on the coagulation system of human plasma have suggested this venom activates factor XI. Incubation with the venom results in a prolongation of the partial thromboplastin times in glass which is associated with a depletion of factors V, VIII, and fibrinogen. The latter may be due to the proteolytic properties of the venom. Soluble fibrin monomer complexes are formed rapidly after addition of the venom to normal plasma. The venom also causes platelet aggregation which is not inhibited by heparin.

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References

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